16081-93-9Relevant academic research and scientific papers
Synthesis and biological evaluation of some 3H-quinazolin-4-one derivatives
Sharaf, Afrah,Ragab, Sherif Shaban,Elbarbary, Ahmed A.,Shaban, Elkhabiry,El Sayed, Ibrahim El Tantawy
, p. 291 - 302 (2021/07/02)
Starting from 3-phenylquinazoline-2,4(1H,3H)-dithione, some new derivatives of 3H-quinazoline-4-ones were synthesized. The structures of all new compounds were inferred based on the mass spectral, infrared, and NMR spectral data as well as the elemental analytical data. Some compounds were chosen for testing their biological activities as antibacterial, antifungal, and anticancer agents. Graphic abstract: [Figure not available: see fulltext.]
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model
Redondo, Miriam,Zarruk, Juan G.,Ceballos, Placido,Pérez, Daniel I.,Pérez, Concepción,Perez-Castillo, Ana,Moro, María A.,Brea, José,Val, Cristina,Cadavid, María I.,Loza, María I.,Campillo, Nuria E.,Martínez, Ana,Gil, Carmen
experimental part, p. 175 - 185 (2012/03/08)
A simple and efficient synthetic method for the preparation of quinazoline type phosphodiesterase 7 (PDE7) inhibitors, based on microwave irradiation, has been developed. The use of this methodology improved yields and reaction times, providing a scalable procedure. These compounds are pharmacologically interesting because of their in vivo efficacy both in spinal cord injury and Parkinson's disease models, as shown in previous studies from our group. Herein we describe for the first time that administration of one of the PDE7 inhibitors here optimized, 3-phenyl-2,4-dithioxo-1,2,3,4-tetrahydroquinazoline (compound 5), ameliorated brain damage and improved behavioral outcome in a permanent middle cerebral artery occlusion (pMCAO) stroke model. Furthermore, we demonstrate that these PDE7 inhibitors are potent anti-inflammatory as well as neuroprotective agents in primary cultures of neural cells. These results led us to propose PDE7 inhibitors as a new class of therapeutic agents for neuroprotection.
USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES
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, (2013/03/26)
The present invention relates to the use of a series of compounds derived from quinazoline for the production of a drug for treating and/or preventing neurological and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. The present invention also relates to a method for treating and/or preventing neurological and neurodegenerative diseases, consisting in administering a therapeutically effective amount of said compounds.
USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES
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, (2013/03/26)
The present invention relates to the use of a series of quinazoline-derived compounds to produce a medicament for the treatment and/or prevention of neurological and/or neurodegenerative diseases, such as Parkinson's disease or Alzheimer's disease. The present invention also relates to a method for the treatment and/prevention of neurological and/neurodegenerative diseases comprising the administration of a therapeutically effective amount of said compounds.
One-pot synthesis of 3-arylquinazoline-2,4(1H,3H)-dithiones by the reaction of 2-lithiophenyl isothiocyanates with aryl isothiocyanates
Kobayashi, Kazuhiro,Yokoi, Yuki,Konishi, Hisatoshi
experimental part, p. 1526 - 1528 (2011/06/22)
3-Arylquinazoline-2,4(1H,3H)-dithiones were synthesized in satisfactory yields from 2-bromophenyl isothiocyanates in one pot via generation of the corresponding 2-lithiophenyl isothiocyanates by bromine-lithium exchange with butyllithium followed by treatment with aryl isothiocyanates. Georg Thieme Verlag Stuttgart · New York.
COMPOUND THAT IS A DUAL INHIBITOR OF ENZYMES PDE7 AND/OR PDE4, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Page/Page column 12, (2009/12/24)
The invention relates to a series of dual inhibitors of enzymes PDE7 and PDE4, having formula (I) and to the use thereof in the production of pharmaceutical compositions for the treatment of inflammatory and/or autoimmune processes.
Influence of the replacement of the oxo function with the thioxo group on the antimycobacterial activity of 3-aryl-6,8-dichloro-2H-1,3-benzoxazine-2,4(3H)-diones and 3-arylquinazoline-2,4(1H,3H)-diones
Waisser, Karel,Gregor, Jiri,Dostal, Hynek,Kunes, Jioi,Kubicova, Lenka,Klimesova, Vera,Kaustova, Jarmila
, p. 803 - 807 (2007/10/03)
Series of 3-phenyl-6,8-dichloro-2H-1,3-benzoxazine-2,4(3H)-dithiones, 3-arylquinazoline-2,4(1H,3H)-diones and 3-arylquinazoline-2,4(1H,3H)-dithiones were synthesized, and the antimycobacterial activities of the derivatives evaluated in vitro. The compound
