1608124-10-2

Upstream product

• 83816-48-2 1-(4-methoxyphenyl)but-3-yn-1-ol 
• 123-11-5 4-methoxy-benzaldehyde 
• 116-11-0 2-Methoxypropene 
• 1608124-04-4 1-methoxy-4-(1-(2-methoxypropan-2-yloxy)but-3-ynyl)benzene 

Downstream Products

• 1608124-12-4 6-(4-methoxyphenyl)-2,2-dimethyldihydro-2H-pyran-4(3H)-one 
• 1608124-16-8 3-fluoro-6-(4-methoxyphenyl)-2,2-dimethyldihydro-2H-pyran-4(3H)-one 
• 1608124-18-0 (E)-4-fluoro-5-hydroxy-1-(4-methoxyphenyl)-5-methylhex-1-en-3-one 
• 1618682-11-3 3-bromo-4-methoxy-6-(4-methoxyphenyl)-2,2-dimethyl-3,6-dihydro-2H-pyran 
• 1618682-12-4 3,5-dibromo-4-methoxy-2-(4-methoxyphenyl)-6,6-dimethyl-3,6-dihydro-2H-pyran 
• 1618682-13-5 3,5-dibromo-4-methoxy-6-(4-methoxyphenyl)-2,2-dimethyl-3,6-dihydro-2H-pyran 

Relevant academic research and scientific papers

3-Fluorotetrahydropyran-4-one derivatives from homopropargyl acetal

A gold(I)-catalysed regioselective method for the preparation of 3-fluoro-tetrahydropyran-4-one derivatives from homopropargyl acetal is reported. A one-pot procedure based on a gold(I)-catalysed Petasis-Ferrier rearrangement/cyclization and subsequent fl

3-Halotetrahydropyran-4-one derivatives from homopropargyl acetal

GRAPHICAL ABSTRACT A gold(I)-catalyzed regioselective method for the preparation of 3-bromo/iodo-tetrahydropyran-4-one derivatives from homopropargyl acetal is reported. A one-pot procedure based on a gold(I)-catalyzed Petasis-Ferrier rearrangement/cyclization and subsequent electrophilic halogenation was developed. Corresponding hemiacetals were not suitable substrates for the formation of the 3-halo-pyran derivatives. The present transformation is a useful method to readily afford highly substituted 3-halo-tetrahydropyran-4-ones, which are suitable substrates in a variety of reactions in further synthesis.