1608129-76-5

Basic information

• Product Name: 5-amino-3-(4-chloro-2-methylphenyl)pyrazole-1-carboxylic acid tert-butyl ester
• Synonyms: 5-amino-3-(4-chloro-2-methylphenyl)pyrazole-1-carboxylic acid tert-butyl ester
• CAS NO: 1608129-76-5
• Molecular Weight: 307.78
• Mol File: 1608129-76-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-amino-3-(4-chloro-2-methylphenyl)pyrazole-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-3-(4-chloro-2-methylphenyl)pyrazole-1-carboxylic acid tert-butyl ester(1608129-76-5)
• EPA Substance Registry System: 5-amino-3-(4-chloro-2-methylphenyl)pyrazole-1-carboxylic acid tert-butyl ester(1608129-76-5)

Safety Data

• Hazardous Substances Data: 1608129-76-5(Hazardous Substances Data)

Upstream product

• 99585-12-3 4-chloro-2-methylbenzoic acid methyl ester 
• 1040724-41-1 5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-ylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1205055-78-2 3-(4-chloro-2-methylphenyl)-3-oxopropanenitrile 
• 7499-07-2 4-chloro-2-methylbenzoic acid 

Downstream Products

• 1608129-80-1 C₁₉H₂₂ClN₃O₄ 

Relevant articles and documents

Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

α7 nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chemistry program we investigated a novel series of α7 nAChR agonists. Starting from molecular docking studies on two series of molecules recently developed in our laboratories, an alternative scaffold was designed attempting to combine the optimal features of these previously identified urea and pyrazole compounds. Based on our previous SAR knowledge and on predicted drug-like properties, a small library was synthesized in parallel manner, affording compounds with excellent α7 nAChR activity, selectivity and preliminary ADME profile.