92812-82-3

Basic information

• Product Name: Fluorodopa
• Synonyms: Fluorodopa;(18F)-6-Fluoro-L-dopa;(S)-3-[3,4-Dihydroxy-6-(18F)fluorophenyl]-2-aminopropionic acid;3,4-Dihydroxy-6-(18F)fluorophenylalanine;6-(18F)Fluoro-3,4-dihydroxy-L-phenylalanine;6-(18F)Fluoro-3,4-dihydroxyphenylalanine;((18)F)Fdopa;(2S)-2-Amino-3-[2-((18)F)fluoro-4,5-dihydroxyphenyl]propanoic acid
• CAS NO: 92812-82-3
• Molecular Formula: C₉H₁₀FNO₄
• Molecular Weight: 215.1784032
• Mol File: 92812-82-3.mol
• Article Data: 37

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.553g/cm³
• Refractive Index: 1.629
• CAS DataBase Reference: Fluorodopa(CAS DataBase Reference)
• NIST Chemistry Reference: Fluorodopa(92812-82-3)
• EPA Substance Registry System: Fluorodopa(92812-82-3)

Safety Data

• Hazardous Substances Data: 92812-82-3(Hazardous Substances Data)

Usage

Uses

Diagnostic aid (brain imaging); radioactive agent. Note—This radiopharmaceutical, labeled with a cyclotron-generated radionuclide, is prepared in individual nuclear medical centers .

InChI:InChI=1/C9H10FNO4/c10-5-3-8(13)7(12)2-4(5)1-6(11)9(14)15/h2-3,6,12-13H,1,11H2,(H,14,15)/t6-/m0/s1/i10-1

Upstream product

• 1403599-75-6 C₂₅H₃₆⁽¹⁸⁾FNO₁₀ 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 1644527-25-2 C₂₃H₃₄⁽¹⁸⁾FNO₈ 
• 1614253-58-5 (S)-tert-butyl-(S)-2-(tritylamino)-3-(5-formyl-4-methoxymethoxy-2-nitro-phenyl)-propionate 
• 1421282-70-3 N-(tert-butoxycarbonyl)-3,4-di(tert-butoxycarbonyloxy)-6-[¹⁸F]fluoro-L-phenylalanine methyl ester 
• 1421282-68-9 C₁₇H₂₄AgNO₆ 
• 1421282-31-6 N-(tert-butoxycarbonyl)-3,4-dimethoxy-6-(1,3,2-dioxaborinane-5,5-dimethyl)-L-phenylalanine methyl ester 
• 1421282-25-8 ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2-iodo-4,5-dimethoxyphenyl)propanoate 
• 1421282-27-0 N-(tert-butoxycarbonyl)-3,4-(dimethoxy)-6-(iodo)-L-phenylalanine methyl ester 

Downstream Products

• 107610-25-3 6-[¹⁸F]fluoro-3,4-dihydroxyphenethylamine 

Relevant articles and documents

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L-dopa precursor compound, preparation method thereof, and preparation method of 18F labeled L-dopa using the same

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Novel preparation method for positron medicine [18F]FDOPA and intermediate thereof

The invention relates to a novel preparation method for a positron medicine [18F]FDOPA and an intermediate thereof, and in particular to a synthesis method for [18F]FDOPA. The preparation method includes the following steps: (img file ='DDA0001356857630000011.TIF' wi='1718' he='312'/) (1) a compound as formula I reacts with an appropriate 18F source to generate a compound as formula II; (2) the compound as formula II undergoes deprotection operation to generate [18F]FDOPA; R1 and R2 are respectively hydroxyl protecting groups; R3 is chosen from any one of halogen-substituted alkyl group and aryl group, or two R3s are formed together into a 5-8-membered ring; R4 is a carboxyl protecting group; and R5 an R6 are respectively chosen from H and an amino protecting group.