160874-85-1

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 107-21-1 ethylene glycol 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 1236889-31-8 (E)-1-fluoro-4-[1-methyl-3-phenyl-2-propen-1-yl]benzene 
• 1250907-52-8 C₁₁H₁₁FO₂ 
• 1250907-71-1 methyl (E)-4-(4-fluorophenyl)-3-butenoate 
• 1229597-21-0 (E)-tert-butyl((4-(4-fluorophenyl)-1-phenylbut-3-en-1-yl)oxy)dimethylsilane 
• 58861-53-3 4-fluorophenylpyridine 
• 144104-44-9 5-(4-fluoro-phenyl)-1H-indole 
• 374554-36-6 5-(4-fluorophenyl)isoquinoline 
• 68049-21-8 5-(4-fluorophenyl)pyrimidine 
• 171819-99-1 3,5-bis(4-fluorophenyl)pyridine 

Relevant academic research and scientific papers

Insight into Copper Catalysis: In Situ Formed Nano Cu2O in Suzuki-Miyaura Cross-Coupling of Aryl/Indolyl Boronates

A ligand-free copper catalyzed Suzuki-Miyaura coupling of 3,5-diiodopyridine with aryl and indole boronates has been explored in good to excellent yields. In situ generation of nano-Cu2O from CuCl2 under the reaction conditions has been discovered for the first time. The generality of the reaction was further demonstrated by the arylation of 5-iodopyrimidine, iodopyridines, iodobenzenes, and diiodobenzenes and resulted in good to moderate yields. Moreover, bisindole alkaloid Scalaridine A has been successfully synthesized in 60% overall yield.

Superstable palladium(0) complex as an air-and thermostable catalyst for Suzuki coupling reactions

An unprecedentedly thermo-and air-stable Pd0 complex from readily available electron-poor trifluoromethylated phosphine was serendipitously discovered. As detailed and comparative DFT calculations indicate, the stability of the complex is associated with unusually strong ligand-ligand noncovalent interactions. The unique stability and the presence of hydrophobic structural elements of the complex offer several practical advantages, which were exploited in catalytic Suzuki-Miyaura coupling reactions.

Aerobic alcohol oxidation coupled to palladium-catalyzed alkene hydroarylation with boronic esters

(Chemical Equation Presented) An oxidation exercise: An aerobic alcohol oxidation coupled with a regioselective palladium-catalyzed reductive functionalization of styrenes and arylboronic esters has been developed (see scheme). The mechanism is thought to proceed by initial oxidation of the solvent to generate a PdII-hydride species, which subsequently reacts with the alkene and arylboronic ester to ultimately generate a new C-C bond.

Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use

Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

Compounds for the Treatment of Periodontal Disease

Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.