16089-71-7Relevant articles and documents
A facile and new method for the synthesis of α-aryl-N-methylnitrones in solvent-free media using silica gel-NaOH
Alavi Nikje,Bigdeli,Imanieh
, p. 1465 - 1468 (2004)
Substituted α-aryl-N-methylnitrones are prepared by the condensation reaction of N-methylhydroxylamine hydrochloride and benzaldehydes in solvent-free media using silica-gel-NaOH catalyst system. The yields are excellent regardless of the electron-donatin
A green synthesis of nitrones in glycerol
Shariatipour, Monire,Jadidinejad, Masoumeh,Heydari, Akbar
, (2019/11/11)
Abstract: An eco-friendly and efficient synthesis of nitrones is presented by condensation of an equimolar amount of aldehydes and N-substituted hydroxylamine hydrochlorides in glycerol as a recyclable solvent-catalyst. This novel protocol provides rapid and mild access to a series of nitrone derivatives in good to excellent yields in the absence of catalyst and base. Graphic abstract: SYNOPSIS In this study, a base-free protocol by using glycerol as the solvent-catalyst was applied for an eco-friendly synthesis of nitrones from the condensation of aldehydes and N-substituted hydroxylaminehydrochlorides.[Figure not available: see fulltext.].
BPh3-Catalyzed [2+3] Cycloaddition of Ph3PCCO with Aldonitrones: Access to 5-Isoxazolidinones with Exocyclic Phosphonium Ylide Moieties
Brar, Amandeep,Unruh, Daniel K.,Ling, Natalie,Krempner, Clemens
, p. 6305 - 6309 (2019/08/20)
A method for the generation of 5-isoxazolidinones with exocyclic phosphonium ylide functionalities via [2+3] cycloaddition of Ph3PCCO and aldonitrones has been developed and applied in the synthesis of 4-alkylidene-5-isoxazolidinones via Wittig olefination. The reaction proceeds by BPh3 catalysis under mild conditions and with a broad substrate scope. A reaction pathway involving the activation of the aldonitrone via interactions with the Lewis acid BPh3 is proposed.