2585-23-1

Usage

Uses

Used in Pharmaceutical Industry:
N-Methyl-4-Nitro-Benzamide is used as an intermediate in the production of various pharmaceuticals. Its role in this industry is crucial for the synthesis of active pharmaceutical ingredients, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, N-Methyl-4-Nitro-Benzamide is employed as an intermediate for the synthesis of agrochemicals. It aids in the creation of compounds that are used to protect crops from pests and diseases, thereby enhancing agricultural productivity.
Used as a Reagent in Organic Synthesis:
N-Methyl-4-Nitro-Benzamide is utilized as a reagent in organic synthesis processes. Its unique chemical properties, particularly the reactivity of its nitro group, make it a valuable component in a range of chemical reactions, facilitating the formation of desired products.
Used as a Precursor to Other Chemicals:
N-Methyl-4-Nitro-Benzamide also serves as a precursor to the synthesis of various other chemicals. Its ability to participate in multiple types of chemical transformations makes it a versatile building block in the chemical industry, contributing to the creation of a wide array of products.

InChI:InChI=1/C8H8N2O3/c1-9-8(11)6-2-4-7(5-3-6)10(12)13/h2-5H,1H3,(H,9,11)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 74-89-5 methylamine 
• 877-80-5 N-methyl-4-nitrobenzylideneamine 
• 1092-52-0 N-(4-methoxyphenyl)-N-methyl-4-nitrobenzamide 
• 593-51-1 methylamine hydrochloride 
• 134814-87-2 Benzoic acid [methyl-(4-nitro-benzoyl)-amino]-methyl ester 
• 3400-27-9 2-methyl-3-p-nitrophenyloxaziridine 
• 62-23-7 4-nitro-benzoic acid 
• 89399-23-5 N-benzyl-N-methyl-4-nitrobenzamide 
• 10342-64-0 p-nitroacetophenone oxime 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 619-80-7 4-nitrobenzamide 
• 1326422-72-3 N-(4-(dimethylamino)benzyl)-N-methyl-4-nitrobenzamide 
• 52898-51-8 N-methoxy-N-methyl-4-nitrobenzamide 

Downstream Products

• 6274-22-2 4-amino-N-methyl-benzamide 
• 20743-51-5 1-methyl-5-(4-nitrophenyl)-1H-tetrazole 
• 82897-03-8 N-methyl-4-nitro-N-nitrosobenzamide 
• 68823-17-6 3-methyl-2-(4-nitro-phenyl)-4,6-dioxo-5-phenyl-5,6-dihydro-4H-[1,3]oxazinium betaine 
• 24472-11-5 N-Brom-N-methyl-4-nitrobenzamid 
• 66124-26-3 N,N'-Dimethyl-(4-nitro)benzamidine 
• 82791-54-6 6,7-Dimethoxy-2-methyl-1-(4-nitro-phenyl)-2H-isoquinolin-3-one 
• 134814-87-2 Benzoic acid [methyl-(4-nitro-benzoyl)-amino]-methyl ester 
• 59476-41-4 N-Methyl-N,4-dinitrobenzamide 
• 62-23-7 4-nitro-benzoic acid 
• 66124-29-6 N,N'-Dimethyl-N-(2,4-dinitro)phenyl-(4-nitro)benzamidine 
• 66124-26-3 N,N'-Dimethyl-4-nitrobenzamidine 
• 1166974-87-3 N-methyl-5-nitro-[1,1'-biphenyl]-2-carboxamide 
• 1439356-98-5 ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities

A series of 2,4-diamino pyrimidine (DAPY) derivatives were designed, synthesized, and evaluated as inhibitors of focal adhesion kinase (FAK) with antitumor and anti-angiogenesis activities. Most compounds effectively suppressed the enzymatic activities of

2-(4-methanoyl) anilino-4-aminopyrimidine derivatives and application thereof

The invention belongs to the technical field of chemical medicines, and particularly relates to 2-(4-methanoyl) anilino-4-aminopyrimidine derivatives and application thereof. According to the invention, nitryl, carboxyl, cyano and the like are adopted to

Trifluoroacetic Acid Hydroxylamine System as Organocatalyst Reagent in a One-Pot Salt Free Process for the Synthesis of Caprolactam and Amides of Industrial Interest

In this work we studied the reactivity of the Trifluoroacetic acid hydroxylamine system in the one step salt free synthesis of amides from ketones. A particular regards was paid to the caprolactam synthesis because of its industrial relevance. Synthesis, reactivity and characterization of the hydroxylamine trifluoroacetate is given. Fast oximation reaction of several ketones was gained at room temperature (1?h of reaction quantitative conversion for several ketones). In the same reactor, by raising the temperature at 383?K, the Beckmann rearrangement of the so obtained oximes is easily accomplished in the presence of three equivalent of TFA. The possibility of obtaining the trifluoroacetate of the hydroxylamine with a modified nitric acid hydrogenation reactions was verified, too. Reuse of solvent and trifluoroacetic acid is easily achieved by distillation. Graphical abstract: Salt free one-pot caprolactam and amides process catalyzed by CF3COOH, in the presence of NH2OH TFA as the oximation agent.[Figure not available: see fulltext.].

A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group

Abstract: A convenient method is proposed for constructing the tetrazole ring by a one-pot reaction of amides with phosphorus oxychloride and sodium azide. A series of 1,5-disubstituted tetrazoles containing an amino or a carboxy group, which present interest as buildings blocks for the synthesis of biologically active substances, were obtained.

4, 6-disubstituted pyridine [3, 2-d] pyrimidine compound as well as preparation and application thereof

The invention belongs to the technical field of medicines. The invention relates to the field of pharmaceutical chemistry, in particular to a 4, 6-disubstituted pyridine [3, 2-d] pyrimidine compound and pharmaceutically acceptable salt thereof, a preparation method of the compound, a pharmaceutical composition taking the compound as an active ingredient, and application of the compound in preparation of an MNK inhibitor and drugs for treating and/or preventing various cancers and/or metabolic diseases. The present invention relates to compounds represented by formulas I, II, III or IV, and pharmaceutically acceptable salts, hydrates, solvates and metabolites thereof, wherein the variables are described in the claims and the description.

Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage under Catalyst-Free Conditions

Conversion of a wide range of N-Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. α-Ketoamide was successfully converted to aryl diketones, while α,β-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagents. A broad substrate scope, excellent yields, and quick conversion are important features of this methodology.

Nickel-catalyzed aminocarbonylation of aryl halides with carbamoylsilanes: efficient synthesis of secondary (primary) aromatic amides

A nickel-catalyzed aminocarbonylation of aryl halides using carbamoylsilane as an amide source leading to corresponding secondary or primary aromatic amides has been developed, in which the methoxymethyl and benzyl were used as amino protecting group. The protocol tolerates a broad range of aryl halides bearing different functional groups to afford good yields of aryl amides under mild reaction conditions. The types and the relative positions of substituents on the aryl ring make a notable impact on the coupling efficiency. The plausible mechanism of nickel-catalyzed aminocarbonylation has been suggested.

Selective N-Monoalkylation of Amide Derivatives with Trialkyl Phosphates

A highly selective and easily handled monoalkylation of primary amide derivatives by using trialkyl phosphates as alkylating reagents in cyclopentyl methyl ether (CPME) was developed. Various monoalkylated amide derivatives were efficiently synthesized by changing the alkyl moiety (e.g., methyl, ethyl, butyl, or benzyl) of the trialkyl phosphate. These phosphate reagents are relatively stable and easily available, and CPME is a useful solvent in process chemistry.

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

Synthesis of Secondary Aromatic Amides via Pd-Catalyzed Aminocarbonylation of Aryl Halides Using Carbamoylsilane as an Amide Source

Using N-methoxymethyl-N-organylcarbamoyl(trimethyl)silanes as secondary amides source, the direct transformation of aryl halides into the corresponding secondary aromatic amides via palladium-catalyzed aminocarbonylation is described. The reactions tolerated a broad range of functional groups on the aryl ring except big steric hindrance of substituent. The types and the relative position of substituents on the aryl ring impact the coupling efficiency.