1609006-20-3

Upstream product

• 91229-91-3 tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate 
• 73789-86-3 4-i-propylbenzyl bromide 
• 1609006-18-9 (2R,4S)-2-(4-isopropylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid 
• 75-04-7 ethylamine 
• 1609006-16-7 (2S,4R)-4-(4-isopropylbenzyl)-di-tert-butyl 5-oxopyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1609006-22-5 (2S,4R)-4-(4-isopropylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid 

Relevant academic research and scientific papers

Diastereospecific synthesis of new 4-substituted l-theanine derivatives

Considering the biological activity of l-theanine as a potent agonist of NMDA receptors, impacting on glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically pure 4-substituted l-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized and correctly protected (S)-pyroglutamate.