73789-86-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Isopropyl benzyl bromide 97 is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Isopropyl benzyl bromide 97 is utilized as a precursor for the production of various agrochemicals, including pesticides and herbicides. Its role in the synthesis of these compounds helps to improve crop protection and yield.
Used in Specialty Chemicals Industry:
4-Isopropyl benzyl bromide 97 is also employed as an intermediate in the synthesis of specialty chemicals, which are used in a wide range of applications, such as fragrances, dyes, and coatings. Its versatility in chemical reactions enables the creation of unique and innovative products in this industry.

InChI:InChI=1/C10H13Br/c1-8(2)10-5-3-9(7-11)4-6-10/h3-6,8H,7H2,1-2H3

Upstream product

• 536-60-7 cuminol 
• 2051-18-5 4-isopropylbenzyl chloride 
• 50-00-0 formaldehyd 
• 98-82-8 Isopropylbenzene 
• 146689-61-4 4,4'-(oxybis(methylene))bis(isopropylbenzene) 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 59230-57-8 4-(i-propyl)benzyl acetate 

Downstream Products

• 26173-64-8 Hydrazinecarbodithioic acid 4-isopropyl-benzyl ester 
• 33456-99-4 triphenyl(isopropylbenzyl)phosphonium bromide 
• 77237-55-9 diethyl p-isopropylbenzylphosphonate 
• 5553-50-4 N-(4-Isopropyl-benzyl)-N-(4-isopropyl-benzyloxy)-carbamidsaeure-ethylester 
• 184879-42-3 2-(4-Chloro-benzyl)-3-(4-isopropyl-phenyl)-2-methyl-propionic acid ethyl ester 
• 4395-87-3 (4-isopropylphenyl)acetonitrile 
• 73441-51-7 N-methyl-4-isopropylbenzylamine 
• 852690-16-5 5-chloro-1-(4-isopropylbenzyl)-2-nitroaniline 
• 26158-36-1 N'-Isopropylidene-hydrazinecarbodithioic acid 4-isopropyl-benzyl ester 
• 26174-55-0 N'-[1-Phenyl-eth-(E)-ylidene]-hydrazinecarbodithioic acid 4-isopropyl-benzyl ester 
• 478374-41-3 {4'-[1-(4-isopropylbenzyloxyimino)ethyl]biphenyl-3-yl}acetic acid 

Relevant academic research and scientific papers

ROR MODULATORS AND THEIR USES

The invention relates to ROR modulators; compositions comprising an effective amount of a ROR modulator; and methods for treating or preventing diseases associated with ROR. The invention is based in part on the discovery of ROR modulators which interact with RORa and/or RORy and thereby inhibit or induce RORa and/or RORy-activity, and RORa- and/or RORy-regulated target gene and protein expression.

Polyvinylpyrrolidone-bromine complex: An efficient polymeric reagent for selective preparation of benzyl bromides in the presence of hexamethyldisilane

Benzylic bromides were conveniently obtained in high yields via the reaction of the corresponding alcohols with crosslinked polyvinylpyrrolidone- bromine complex (PVPP-Br2)/hexamethyldisilane in chloroform at reflux condition. Selective conversion of benzyl alcohol to benzyl bromide in the presence of primary aliphatic alcohols, e.g. 2-phenylethanol was also achieved.

An efficient synthesis of benzyl bromides from aromatic aldehydes using polymethylhydrosiloxane and (bromodimethyl)sulfonium bromide or N-bromosuccinimide

Polymethylhydrosiloxane (PMHS) in combination with (bromodimethyl)sulfonium bromide or NBS has been utilized for the first time for reductive bromination of aromatic aldehydes at room temperature to afford the corresponding benzyl bromides in excellent yields.

A mild, phosphine-free method for the conversion of alcohols into halides (Cl, Br, I) via the corresponding O-alkyl isoureas

A novel procedure for the conversion of primary and secondary alcohols into the corresponding alkyl chlorides, bromides and iodides is described. The transformation is high-yielding in the case of chlorides and bromides, tolerates a range of functional groups, and does not rely on the use of phosphines.

Method for treating glaucoma

Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.

Prevention of loss and restoration of bone mass by certain prostaglandin agonists

Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis. STR1

Bromomethylation of aromatics mediated by low frequency ultrasound

We report herein bromomethylation of aromatics mediated by low frequency ultrasound to yield bromomethylated aromatic rings which are useful synthetic intermediates.

Use of conjugated dienones in cyclialkylations: The total syntheses of (±)-barbatusol, (±)-pisiferin, (±)-deoxofaveline, (±)-xochitlolone, and (±)-faveline

Concise syntheses of five tricyclic diterpenoids are reported. The key reaction in each synthesis is a cyclialkylation of a functionalized arene with a Lewis acid-activated conjugated dienone to generate a 6,7,6-fused tricycle.

Substituent effects on benzylic radical hydrogen hyperfine coupling constants. Part 4. The effect of branching of the alkyl substituent

The effects of substituents in the meta and para positions of the benzyl radical on the α-hydrogen hyperfine coupling constants (hfc's) are discussed.The electron spin resonance (esr) spectra of the para-methyl, ethyl, isopropyl, and tert-butyl substituted benzyl and cumyl radicals are analysed.Hyperconjugation involving the C-C bond is 40-60percent as effective as C-H hyperconjugation for delocalizing spin density.This conclusion is supported by INDO molecular orbital calculations.Similar analysis of the 13Cmr spectra of the para-alkyl substituted cumyl carbocations provides evidence that C-C hyperconjugation is 75-90percent as effective as C-H hyperconjugation for delocalizing charge density.

Unidirectional Dieckmann Cyclizations on a Solid Phase and in Solution

Dieckmann cyclization of 2percent divinylbenzene-copolystyrene resin alkyl pimelates and analogous benzyl alkyl pimelates is reported.The use of uniquely single-labeled dioate esters has allowed analysis of the direction of closure via decarboxylation of the keto ester products.The influence of steric factors on the competition between enolate condensation and transesterification and upon the direction of closure of the cyclization has been evaluated, and the conditions for achieving >99percent regioselective closure are described.Modifications in the conditions of solid-phase peptide synthesis required for successful high-temperature enolate cyclization have been developed and the results are compared to solution reactions of benzyl alkyl esters under similar conditions.The resin attachment afforded a clear benefit over the benzyl models and greatly simplified isolation and purification of the resulting β-keto esters.