1609102-23-9

Upstream product

• 1609102-12-6 7-chloro-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridine-3-carboxylic acid 
• 1609102-13-7 3-bromo-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one 
• 1609102-14-8 7-chloro-3-iodo-1-methyl-1,6-naphthyridin-2(1H)-one 
• 449811-29-4 6-chloro-4-(methylamino)pyridine-3-carbaldehyde 
• 449811-28-3 ethyl 6-chloro-4-(methylamino)pyridine-3-carboxylate 
• 449811-30-7 (6-chloro-4-(methylamino)pyridin-3-yl)methanol 
• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 
• 40296-46-6 ethyl 4,6-dichloronicotinate 
• 1588423-44-2 7-chloro-1-methyl-3-phenyl-1,6-naphthyridin-2-(1H)-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 

Relevant academic research and scientific papers

Differential functionalization of 1,6-naphthyridin-2(1H)-ones through sequential one-pot Suzuki-Miyaura cross-couplings

A practical synthesis of 7-chloro-3-iodo-1-methyl-1,6-naphthyridin-2(1H)- one is described that starts from 2-chloro-4-(methylamino)nicotinaldehyde. The dihalo compound then undergoes sequential, site-selective Suzuki-Miyaura cross-coupling reactions to afford highly functionalized 1,6-naphthyridones in good yields. One-pot, sequential, site-selective Suzuki-Miyaura cross-coupling reactions of 7-chloro-3-iodo-1-methyl-1,6-naphthyridin-2(1H)-one afforded highly functionalized 1,6-naphthyridones in good yields. Copyright

Differential Functionalization of 1,6-Naphthyridin-2(1H)-ones through Sequential One-Pot Suzuki-Miyaura Cross-Couplings

A practical synthesis of 7-chloro-3-iodo-1-methyl-1,6-naphthyridin-2(1H)-one is described that starts from 2-chloro-4-(methylamino)nicotinaldehyde. The dihalo compound then undergoes sequential, site-selective Suzuki-Miyaura cross-coupling reactions to afford highly functionalized 1,6-naphthyridones in good yields.