1609192-26-8Relevant articles and documents
The new mangiferin chemical synthesis method and intermediate compound
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Paragraph 0071-0072, (2017/10/31)
The invention discloses a chemical semi-synthesis method of neomangiferin. The chemical semi-synthesis method comprises the following steps of sequentially carrying out acylation and protecting group conversion on mangiferin used as a starting material and selectively removing phenolacyl groups so as to obtain an intermediate compound represented by the formula D as shown in the description; carrying out glycosylation reaction by using bromotetraacyl glucose as a donor and a phase-transfer catalytic method to obtain an ntermediate compound represented by the formula E as shown in the description and finally removing acyl protecting groups under catalytic hydrogenation, or acid hydrolysis, or reduction and basic conditions to obtain neomangiferin, wherein the definitions of substituent groups in the formulas D and E are shown in the description. The chemical semi-synthesis method has the characteristics of mild reaction conditions, high yield, simplicity in operation, relatively low cost, high universality and like, is suitable for industrial mass production and has better application prospects.