1609211-15-5

Basic information

• Product Name: N-(4′-chloro-[1,1′-biphenyl]-2-yl)picolinamide
• Synonyms: N-(4′-chloro-[1,1′-biphenyl]-2-yl)picolinamide
• CAS NO: 1609211-15-5
• Molecular Weight: 308.767
• Mol File: 1609211-15-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4′-chloro-[1,1′-biphenyl]-2-yl)picolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4′-chloro-[1,1′-biphenyl]-2-yl)picolinamide(1609211-15-5)
• EPA Substance Registry System: N-(4′-chloro-[1,1′-biphenyl]-2-yl)picolinamide(1609211-15-5)

Safety Data

• Hazardous Substances Data: 1609211-15-5(Hazardous Substances Data)

Upstream product

• 615-43-0 2-iodophenylamine 
• 98-98-6 2-Picolinic acid 
• 1204-44-0 2-(4-chlorophenyl)aniline 
• 1679-18-1 4-Chlorophenylboronic acid 
• 39901-94-5 2-picolinoyl chloride hydrochloride 
• 615-36-1 2-bromoaniline 

Downstream Products

• 10537-08-3 2-chloro-9H-carbazole 
• 26844-83-7 8-chlorophenanthridin-6(5H)-one 

Relevant articles and documents

Metal-Oxidant-Free Cobalt-Catalyzed C(sp2)-H Carbonylation of ortho-Arylanilines: An Approach toward Free (NH)-Phenanthridinones

A traceless directing group assisted Co-catalyzed C(sp2)-H carbonylation of ortho-arylanilines for the synthesis of free (NH)-phenanthridinones in metal-based-oxidant-free fashion was accomplished. This protocol employs diisopropyl azodicarboxylate as the CO source and oxygen as the sole oxidant, and provides good yields with various functional tolerance. The methodology has been applied for the total synthesis of PARP inhibitor PJ-34. Furthermore, the kinetic isotopic effect experiments reveal the C-H bond cleavage probably occurred in the rate-determining step.