160929-07-7

Upstream product

• 100-39-0 benzyl bromide 
• 87280-21-5 N-(2-bromo-2-propen-1-yl)-N-(2-propen-1-yl)amine 
• 72551-10-1 N-(2-bromoallyl)benzylamine 
• 106-95-6 allyl bromide 

Downstream Products

• 50586-30-6 1-Benzyl-3,4-dimethylenepyrrolidine 
• 119548-54-8 N-benzyl-5-methylene-1,2,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

Convenient synthesis of heterobicycles by domino Heck-Diels-Alder reactions

Palladium(0)-catalyzed intramolecular cross coupling of bromodialkenylamines, bromoalkenylalkenamides and bromodialkenyl ethers followed by in situ [4+2] cycloaddition with suitable dienophiles gave tetrahydroisoindolines (31-73%yield), tetrahydroisoindolin-1-ones (43-51%) and hexahydrobenzo[c]furans (35-55%), and hexahydro-1H-[2]pyrindines (66-75%), respectively, each in one-pot operations.

Suppressed β-hydride elimination in palladium-catalyzed cascade cyclization-coupling reactions: An efficient synthesis of 3-arylmethylpyrrolidines

(formula presented) A novel type of palladium-catalyzed cascade cyclization-coupling reaction that proceeds with suppressed β-hydride elimination has been found. One of the N-sulfonyl oxygens is suggested to coordinatively stabilize an alkylpalladium inte