1609324-12-0

Basic information

• Product Name: 1-(2-amino-phenyl)-3-trimethylsilanyl-propan-1-one
• Synonyms: 1-(2-amino-phenyl)-3-trimethylsilanyl-propan-1-one
• CAS NO: 1609324-12-0
• Molecular Weight: 221.374
• Mol File: 1609324-12-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-amino-phenyl)-3-trimethylsilanyl-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-amino-phenyl)-3-trimethylsilanyl-propan-1-one(1609324-12-0)
• EPA Substance Registry System: 1-(2-amino-phenyl)-3-trimethylsilanyl-propan-1-one(1609324-12-0)

Safety Data

• Hazardous Substances Data: 1609324-12-0(Hazardous Substances Data)

Upstream product

• 1609257-45-5 1-(2-nitrophenyl)-3-(trimethylsilyl)prop-2-yn-1-one 
• 41309-43-7 (2-bromovinyl)trimethylsilane 
• 78389-87-4 ((trimethylsilyl)ethynyl)zinc(II) chloride 
• 610-14-0 2-nitrobenzyl chloride 
• 1072913-33-7 1-(2-nitrophenyl)-3-(trimethylsilyl)prop-2-yn-1-ol 
• 1609257-35-3 1-(2-nitrophenyl)-3-trimethylsilanyl-propenone 
• 552-89-6 2-nitro-benzaldehyde 
• 1609257-47-7 C₁₂H₁₇NO₃Si 
• 42201-74-1 2-trimethylsilylethenylmagnesium bromide 

Downstream Products

• 1609257-46-6 1-(2-aminophenyl)-3-(trimethylsilyl)propan-1-one hydrochloride 
• 203923-89-1 (4S)-4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3':4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 

Relevant articles and documents

Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin

The present invention discloses and claims five (5) novel, highly efficient synthetic routes for the total synthesis of enantiomerically-pure (i.e., 99%) 7-(2′-trimethylsilyl)ethyl camptothecin (BNP1350; Karenitecin; Cositecan). These aforementioned synthetic schemes are the first to disclose the total syntheses of 7-(2′-trimethylsilyl)ethyl camptothecin using a highly novel direct, non-linear and convergent synthetic strategy which involves annealing the key C7-(trimethylsilyl)ethyl side chain-bearing A ring key synthons to an enantiomerically-pure tricyclic pyridone; rather than through the conventional methodology which incorporates the C7-(trimethylsilyl)ethyl side chain as the final synthetic step on a totally synthesized camptothecin parent compound. The current novel synthetic approaches reported herein since utilize desirably functionalized A-ring with preinstalled trimethyl silyl ethyl side chain, the aforementioned synthetic methodologies have a wider scope of making wide range of pharmaceutically relevant A-ring substituted BNP1350 analogs by substituting desirably functionalized nitro or protected amino phenyl carboxy A-ring as the starting material.