42201-74-1

Basic information

• Product Name: 1-trimethylsilylvinylmagnesium bromide
• CAS NO: 42201-74-1
• Molecular Weight: 203.437
• Mol File: 42201-74-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-trimethylsilylvinylmagnesium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-trimethylsilylvinylmagnesium bromide(42201-74-1)
• EPA Substance Registry System: 1-trimethylsilylvinylmagnesium bromide(42201-74-1)

Safety Data

• Hazardous Substances Data: 42201-74-1(Hazardous Substances Data)

Upstream product

• 41309-43-7 (2-bromovinyl)trimethylsilane 

Downstream Products

• 108585-57-5 (E)-1-(3-Phenyl-cyclohex-1-enyl)-3-trimethylsilanyl-prop-2-en-1-ol 
• 108585-56-4 (E)-3-Trimethylsilanyl-1-(3-vinyl-cyclohex-1-enyl)-prop-2-en-1-ol 
• 108585-58-6 (E)-1-(3-tert-Butyl-cyclohex-1-enyl)-3-trimethylsilanyl-prop-2-en-1-ol 
• 108585-59-7 (E)-1-(3-Benzyloxymethoxymethyl-cyclohex-1-enyl)-3-trimethylsilanyl-prop-2-en-1-ol 
• 97204-53-0 (2R,3R)-3-(1-Trimethylsilanyl-vinyl)-1-trityloxy-heptan-2-ol 
• 203923-89-1 (4S)-4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3':4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 
• 1609257-35-3 1-(2-nitrophenyl)-3-trimethylsilanyl-propenone 
• 1609324-12-0 1-(2-amino-phenyl)-3-trimethylsilanyl-propan-1-one 
• 1609257-46-6 1-(2-aminophenyl)-3-(trimethylsilyl)propan-1-one hydrochloride 
• 1609257-47-7 C₁₂H₁₇NO₃Si 
• 120764-61-6 Trimethyl-((1E,3E)-7-phenyl-hepta-1,3-dienyl)-silane 
• 120764-60-5 (1E,3Z)-7-phenyl-1-trimethylsilyl-1,3-heptadiene 
• 70960-88-2 trimethyl ((1E,3E)-4-phenylbuta-1,3-dien-1-yl)silane 
• 84247-81-4 (1E,3Z)-1-trimethylsilyl-4-phenyl-1,3-butadiene 

Relevant articles and documents

Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin

The present invention discloses and claims five (5) novel, highly efficient synthetic routes for the total synthesis of enantiomerically-pure (i.e., 99%) 7-(2′-trimethylsilyl)ethyl camptothecin (BNP1350; Karenitecin; Cositecan). These aforementioned synthetic schemes are the first to disclose the total syntheses of 7-(2′-trimethylsilyl)ethyl camptothecin using a highly novel direct, non-linear and convergent synthetic strategy which involves annealing the key C7-(trimethylsilyl)ethyl side chain-bearing A ring key synthons to an enantiomerically-pure tricyclic pyridone; rather than through the conventional methodology which incorporates the C7-(trimethylsilyl)ethyl side chain as the final synthetic step on a totally synthesized camptothecin parent compound. The current novel synthetic approaches reported herein since utilize desirably functionalized A-ring with preinstalled trimethyl silyl ethyl side chain, the aforementioned synthetic methodologies have a wider scope of making wide range of pharmaceutically relevant A-ring substituted BNP1350 analogs by substituting desirably functionalized nitro or protected amino phenyl carboxy A-ring as the starting material.