160946-75-8

Upstream product

• 289698-26-6 C₁₅H₁₇Cl₂OPSi 
• 40438-48-0 diphenylmethylsilylethylethanol 
• 158852-07-4 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite) 
• 21090-30-2 3'-O-acetylthymidine 
• 155398-45-1 (2-diphenylmethylsilylethoxy)bis(N,N-diisopropylamino)phosphine 
• 182966-92-3 C₅₈H₆₃N₄O₁₄PSSi 

Relevant academic research and scientific papers

Synthesis and deprotection of β-silylethyl protected O,O,O-and O,O,S-trialkylphosphorothioates

Functionalized 2-(diphenylmethylsilyl)ethyl protected thymidyl-thymidine phosphorothioate dimers are easily accessible and stable under conditions used in oligophosphorothioate synthesis. Deprotection with ammonium hydroxide occurs through β-fragmentation. Methylamine and tetrabutyl-ammonium fluoride rapidly and selectively remove the DPSE protecting group of O,O,O-and O,O,S-trialkylphosphorothioates.

Phosphorothioate: β-Fragmentierung gegen β-Silicium-Effekt

Keywords: Antisense-Oligonucleotide, Nachbargruppeneffekte, Nucleotide, Phosphorverbindungen, Umlagerungen