40438-48-0

Usage

Uses

Used in Chemical Synthesis:
2-(METHYLDIPHENYLSILYL)ETHANOL is used as a key intermediate in the preparation of 2-diphenylmethylsilylethyldithiophosphorodichloridate. 2-(METHYLDIPHENYLSILYL)ETHANOL is an important precursor in the synthesis of various organophosphorus compounds, which have applications in pharmaceuticals, agrochemicals, and other industries.

InChI:InChI=1/C15H18OSi/c1-17(13-12-16,14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16H,12-13H2,1H3

Upstream product

• 144-79-6 chloromethyldiphenylsilane 
• 77772-21-5 tert-butyl α-(methyldiphenylsilyl)acetate 

Downstream Products

• 73364-60-0 Dithiophosphoric acid S,S'-bis-(4-methoxy-phenyl) ester O-[2-(methyl-diphenyl-silanyl)-ethyl] ester 
• 155398-45-1 (2-diphenylmethylsilylethoxy)bis(N,N-diisopropylamino)phosphine 
• 158817-18-6 bis<2-(methyldiphenylsilyl)ethyl> N,N-diisopropylphosphoramidite 
• 162554-42-9 bis<2-(methyldiphenylsilyl)ethyl> N,N-diethylphosphoramidite 
• 158852-07-4 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite) 
• 40438-47-9 diethyl 2-(diphenyl methylsilyl)-ethyl phosphate 
• 79284-75-6 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate 
• 73364-59-7 2-diphenylmethylsilylethyl S-p-methoxyphenyl phosphorothioate 
• 79284-77-8 Thiophosphoric acid O-[(2S,3R,5S)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-methoxy-phenyl) ester O'-[2-(methyl-diphenyl-silanyl)-ethyl] ester 
• 158817-11-9 N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine 
• 158817-12-0 N^α-(benzyloxycarbonyl)-O-phosphono>tyrosine benzyl ester 
• 182966-92-3 C₅₈H₆₃N₄O₁₄PSSi 

Relevant academic research and scientific papers

Synthesis and Application of Bis-Silylethyl-Derived Phosphate-Protected Fmoc-Phosphotyrosine Derivatives for Peptide Synthesis

Three Fmoc-phosphotyrosine derivatives with silylethyl-based phosphate protection were synthesized and evaluated for use in peptide synthesis.The stability of these derivatives toward piperidine/DMF (1:4) treatment and their cleavability with TFA solutions were examined.On the basis of these data, the bis-protected Fmoc-phosphotyrosine derivative or Fmoc-Tyr(PO3MDPSE2)-OH, was shown to be the most suitable candidate for the production of phosphotyrosine peptides.The syntheses of phosphotyrosine peptides including one containing Met and Cys are described.

2-DIPHENYLMETHYLSILYLETHYL GROUP AS A NEW PROTECTING GROUP OF INTERNUCLEOTIDIC PHOSPHATES IN OLIGONUCLEOTIDE SYNTHESIS

Internucleotidic phosphates were protected by 2-diphenylmethylsilylethyl group which was selectively removed by treatment with tetrabutylammonium fluoride.