1609632-76-9

Upstream product

• 189031-66-1 N-(tert-butoxycarbonyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 1298087-03-2 N-(3-(4-bromophenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide 
• 41658-03-1 ethyl 3-bromoprop-2-ynoate 
• 55022-46-3 4-methyl-N-prop-2-ynylbenzenesulfonamide 

Relevant academic research and scientific papers

Access to cyclobutene-fused azepines through au-catalyzed cycloisomerization of stable alkyne tethered ketene N,N -acetals

A base promoted reaction between N-protected propargyl amines and 3-bromopropiolate readily provides an array of novel stable alkyne-tethered ketene N,N-acetals in good yields. A wide range of structurally complex cyclobutene-fused azepine heterocycles are synthesized through the gold-catalyzed intramolecular cycloisomerization of ketene N,N-acetals for the first time. A plausible reaction pathway is deduced on the basis of the 1H NMR studies.