1609643-88-0Relevant academic research and scientific papers
Rapid, Stoichiometric, Site-Specific Modification of Aldehyde-Containing Proteins Using a Tandem Knoevenagel-Intra Michael Addition Reaction
Yu, Jian,Shen, Da,Zhang, Hanjie,Yin, Zheng
, p. 1016 - 1020 (2018/04/23)
A site-specific modification of aldehyde-containing proteins using a tandem Knoevenagel-intra Michael addition reaction was developed. The reaction featured fast kinetics (50 M-1 s-1) and favorable stoichiometry. Various functionalities could be introduced into the protein with little impact on its function and conformation. The reaction was successfully applied in the labeling of living cells.
COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE
-
, (2014/05/24)
The present disclosure provides conjugate structures and compound structures used to produce these conjugates. Also provided are methods of producing drug-polypeptide or detectable label-polypeptide conjugates linked through a modified amino acid. Structures of the modified amino acids used in producing the conjugates are disclosed.
