1609689-75-9

Upstream product

• 873-75-6 4-bromobenzenemethanol 
• 144332-75-2 pBrZ-L-Pro-OH 
• 1618080-03-7 C₂₄H₂₆BrN₃O₆ 
• 38065-38-2 (4-bromophenyl)methyl 4-nitrophenyl carbonate 
• 144332-74-1 (S)-1-(4-bromobenzyl)2-methyl pyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1609689-87-3 (S)-(3’-tert-butyl-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-88-4 (S)-(4’-tert-butyl-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-89-5 (S)-(3’-fluoro-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-90-8 (S)-(4’-fluoro-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-91-9 (S)-(3’,5’-fluoro-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-92-0 (S)-(2’,3’-fluoro-[1,1’-biphenyl]-4-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-93-1 (S)-(3’,4’-fluoro-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-94-2 (S)-(2’,4’-fluoro-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-95-3 (S)-(3’-chloro-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-96-4 (S)-(4’-chloro-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-98-6 (S)-(3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-99-7 (S)-(4’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609690-00-7 (S)-(4’-methoxy-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609690-01-8 (S)-(3’-methoxy-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

This Letter describes the further development and SAR exploration of a novel series of Legumain inhibitors. Based upon a previously identified Legumain inhibitor from our group, we explored the SAR of the carbamate phenyl ring system to probe the P3 pocke