160977-92-4Relevant academic research and scientific papers
COMPOUNDS AS TNIK, IKKEPSILON AND TBK1 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
-
Paragraph 0889-0892, (2016/11/14)
Provided is a compound of formula (I) as a TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the compound according to the present invention effectively inhibits TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
Synthesis and NMR Studies of N-Substituted Derivatives of Kainic Acid Dimethyl Esters
Papaioannou, Dionissios,Sivas, Manolis,Kouvelas, Elias,Francis, George W.,Aksnes, Dagfinn W.
, p. 831 - 836 (2007/10/02)
Dimethyl kainate derivatives incorporating the amino protecting groups, 9-fluorenylmethoxycarbonyl (Fmoc), tert-butoxycarbonyl (Boc) and triphenylmethyl (trityl, Trt), have been synthesized from (-)-α-kainic acid (2S,3S,4S)-2-carboxy-4-(1-methylethenyl)-
