16099-37-9

Upstream product

• 100190-35-0 (R)-4-tert-butyl-1-[(trimethylsilyl)oxy]cyclohexene 
• 100-39-0 benzyl bromide 
• 100190-34-9 (S)-4-tert-butyl-1-(trimethylsilyloxy)cyclohexene 
• 100-52-7 benzaldehyde 
• 19980-19-9 4-t-butyl-1-trimethylsilyloxy-1-cyclohexene 
• 88044-20-6 (2S,4S)-4-tert-Butyl-2-(hydroxy-phenyl-methyl)-cyclohexanone 
• 88044-20-6 (2S,4R)-4-tert-Butyl-2-(hydroxy-phenyl-methyl)-cyclohexanone 

Relevant academic research and scientific papers

Control of Diastereoelectivity in Alkylation of Chiral Lithium Enolates Mediated by a Chiral Secondary Amine Ligand

Diastereoselective alkylation of chiral lithium enolates (dl-, (R)- and (S)-9) derived from 4-t-butylcyclohexanone in the presence of a chiral secondary amine (R)-1 and lithium bromide was studied.It is shown that (R)-1 regulates the direction of the attack of electrophiles.Thus highly stereoselective axial attack was observed on (R)-9, while equatorial attack on (S)-9.The present method provides an efficient procedure for the asymmetric synthesis of 2,4-disubstituted cyclohexanones.

ALDOL REACTION OF TRICHLOROTITANIUM ENOLATES. REVALUATION OF THE BOAT TRANSITION STATE

The trichlorotitanium enolates generally undergo an erythro selective aldol reaction except one case which gives a threo aldol.A new form of the boat transition state has been proposed.