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3α,11β-Dihydroxy-5β-pregnan-20-one, also known as Allopregnanolone, is a naturally occurring steroid hormone derived from the parent compound pregnane. It is a metabolite of the hormone pregnenolone and plays a significant role in the endocrine system. Allopregnanolone is known for its neuroactive properties, particularly in the central nervous system, where it acts as a positive allosteric modulator of the GABA-A receptor. This action helps to enhance the inhibitory effects of GABA, leading to a calming effect on the nervous system. The compound has been studied for its potential therapeutic applications in various conditions, including anxiety, depression, and certain neurological disorders. It is also involved in the regulation of stress responses and may influence mood and cognition. Allopregnanolone is an important compound in the field of neurosteroids, which are steroids that can affect the nervous system.

565-92-4

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565-92-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 565-92-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 565-92:
(5*5)+(4*6)+(3*5)+(2*9)+(1*2)=84
84 % 10 = 4
So 565-92-4 is a valid CAS Registry Number.

565-92-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5β-pregnan-3α,11β-diol-20-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:565-92-4 SDS

565-92-4Relevant academic research and scientific papers

Allopregnanolone and pregnanolone analogues modified in the C ring: Synthesis and activity

Slavíková, Barbora,Bujons, Jordi,Matyá?, Libor,Vidal, Miguel,Babot, Zoila,Kri?tofíková, Zdena,Su?ol, Cristina,Kasal, Alexander

, p. 2323 - 2336 (2013/06/04)

(25R)-3β-Hydroxy-5α-spirostan-12-one (hecogenin) and 11α-hydroxypregn-4-ene-3,20-dione (11α-hydroxyprogesterone) were used as starting materials for the synthesis of a series of 11- and 12-substituted derivatives of 5ξ-pregnanolone (3α-hydroxy-5α- pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one), the principal neurosteroid acting via γ-aminobutyric acid (GABA). These analogues were designed to study the structural requirements of the corresponding GABA A receptor. Their biological activity was measured by in vitro test with [3H]flunitrazepam as radioligand in which allopregnanolone and its active analogues stimulated the binding to the GABAA receptor. Analysis of the SAR data suggests dependence of the flunitrazepam binding activity on the hydrophobic-hydrophilic balance of the groups at the C-ring edge rather than on specific interactions between them and the receptor.

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