1610353-91-7Relevant academic research and scientific papers
Catalytic enantioselective silylation of N-sulfonylimines: Asymmetric synthesis of α-amino acids from CO2 via stereospecific carboxylation of α-amino silanes
Mita, Tsuyoshi,Sugawara, Masumi,Saito, Keisuke,Sato, Yoshihiro
, p. 3028 - 3031 (2014/06/23)
A catalytic enantioselective silylation of N-tert-butylsulfonylimines using a Cu-secondary diamine complex was demonstrated. The resulting optically active α-amino silanes could be carboxylated under a CO2 atmosphere (1 atm) to afford the corresponding α-amino acids in a stereoretentive manner. This two-step sequence provides a new synthetic protocol for optically active α-amino acids from gaseous CO2 and imines in the presence of a catalytic amount of a chiral source.
