16105-77-4

Basic information

• Product Name: FENFLURAMINE HYDROCHLORIDE
• Synonyms: dl-fenfluraminehydrochloride;n-ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanaminehydrochloride(+-)-;n-ethyl-alpha-methyl-m-(trifluoromethyl)-,hydrochloride,(+-phenethylamin;racemicfenfluraminehydrochloride;FENFLURAMINE HCL;FEBFLURAMINE HYDROCHLORIDE;N-ETHYL-ALPHA-METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE;N-ETHYL-ALPHA-METHYL-M-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE
• CAS NO: 16105-77-4
• Molecular Formula: C12H17ClF3N
• Molecular Weight: 267.72
• Product Categories: AmphetamineAlphabetic;FA - FLForensic and Veterinary Standards;Chemical Structure;Drugs of Abuse;Drugs&Metabolites;F;Neat Compounds
• Mol File: 16105-77-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 166 C
• Boiling Point: 243.1°Cat760mmHg
• Flash Point: 11 °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: FENFLURAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: FENFLURAMINE HYDROCHLORIDE(16105-77-4)
• EPA Substance Registry System: FENFLURAMINE HYDROCHLORIDE(16105-77-4)

Safety Data

• Hazard Codes: T,F,Xi
• Statements: 25-39/23/24/25-23/24/25-11-36/37/38
• Safety Statements: 7-16-36/37-45-28-22-36-26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: DA0295500
• Hazardous Substances Data: 16105-77-4(Hazardous Substances Data)

Upstream product

• 458-24-2 Fenfluramine 
• 351-35-9 3-(trifluoromethyl)phenylacetic acid 
• 2338-76-3 3-trifluoromethylphenylacetonitrile 
• 21906-39-8 3-(trifluoromethyl)phenylacetone 
• 98-16-8 3-trifluoromethylaniline 
• 217320-76-8 (S),(S)-N-ethyl-N-(1-phenylethyl)-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride 
• 78-93-3 butanone 
• 108-10-1 4-methyl-2-pentanone 
• 557-66-4 ethanamine hydrochloride 

Relevant articles and documents

POLYMORPH OF N-ETHYL-1-(3-(TRIFLUOROMETHYL)PHENYL)PROPAN-2-AMINE HYDROCHLORIDE AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a crystalline form of N-ethyl-1-(3-(trifluoro methyl) phenyl) propan-2-amine hydrochloride compound of formula-1, which is represented by the following structural formula. The present invention also relates to process for the preparation of crystalline form of compound of formula-1 and process for the preparation of compound of formula-1.

FENFLURAMINE COMPOSITIONS AND METHODS OF PREPARING THE SAME

Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.

Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents

A method for the treatment of emesis in a mammal, which method comprises administering to said mammal an emesis inhibiting amount of a compound which depletes serotonin in the brain of mammals; among which are compounds having the formula: STR1 wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R1 and R2 are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof; two of the preferred compounds of the invention are fenfluramine and norfenfluramine.