1610591-49-5

Basic information

• Product Name: (Z)-3-chloro-2-(2-methoxyphenyl)-1-phenylprop-2-en-1-one
• Synonyms: (Z)-3-chloro-2-(2-methoxyphenyl)-1-phenylprop-2-en-1-one
• CAS NO: 1610591-49-5
• Molecular Weight: 272.731
• Mol File: 1610591-49-5.mol

Chemical Properties

• CAS DataBase Reference: (Z)-3-chloro-2-(2-methoxyphenyl)-1-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-chloro-2-(2-methoxyphenyl)-1-phenylprop-2-en-1-one(1610591-49-5)
• EPA Substance Registry System: (Z)-3-chloro-2-(2-methoxyphenyl)-1-phenylprop-2-en-1-one(1610591-49-5)

Safety Data

• Hazardous Substances Data: 1610591-49-5(Hazardous Substances Data)

Upstream product

• 854630-15-2 2-(2-methoxyphenyl)-3-oxo-3-phenylpropanal 

Downstream Products

• 37883-64-0 3-(2-phenyl-1-benzofuran)carbaldehyde 
• 1610591-71-3 3-(dibromomethyl)-2-phenylbenzo[b]furan 

Relevant articles and documents

A novel efficient protocol for preparation of 3-formyl-2-arylbenzo[b]furan derivatives

An efficient method for preparation of 3-formyl-2-arylbenzo[b]furan derivatives 4 from 3-chloro-2-(2-methoxyaryl)-1-arylprop-2-en-1-one 2 was developed, and the desired product was obtained in good to excellent yields. By converting 2-(2-methoxyphenyl)-3-oxo-3-phenylpropanal 1 to 2, the regioselectivity problem occurring in the reaction when using 1 as the starting material was successfully avoided. Furthermore, a one-pot procedure for the successive demethylation, cyclization, and hydrolysis was evolved, although the intermediate 3-(dibromomethyl)-2-phenylbenzo[b]furan 3a could be isolated. A plausible mechanism was proposed based on some in situ investigations.