1610591-71-3Relevant academic research and scientific papers
A novel efficient protocol for preparation of 3-formyl-2-arylbenzo[b]furan derivatives
Liao, Benren,Ruan, Libo,Shi, Min,Li, Nian,Chang, Liang,Liu, Leping,Yang, Fan,Tang, Jie
supporting information, p. 3274 - 3277 (2014/06/09)
An efficient method for preparation of 3-formyl-2-arylbenzo[b]furan derivatives 4 from 3-chloro-2-(2-methoxyaryl)-1-arylprop-2-en-1-one 2 was developed, and the desired product was obtained in good to excellent yields. By converting 2-(2-methoxyphenyl)-3-oxo-3-phenylpropanal 1 to 2, the regioselectivity problem occurring in the reaction when using 1 as the starting material was successfully avoided. Furthermore, a one-pot procedure for the successive demethylation, cyclization, and hydrolysis was evolved, although the intermediate 3-(dibromomethyl)-2-phenylbenzo[b]furan 3a could be isolated. A plausible mechanism was proposed based on some in situ investigations.
