1610693-06-5

Upstream product

• 40882-43-7 3,4-dichloro-5-ethoxy-2,5-dihydrofuran-2-one 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 106-45-6 para-thiocresol 
• 1610693-00-9 3-chloro-5-ethoxy-4-(4-methylphenylsulfanyl)furan-2(5H)-one 

Relevant academic research and scientific papers

Synthesis of amino acid derivatives of 5-alkoxy-3,4-dihalo-2(5: H)-furanones and their preliminary bioactivity investigation as linkers

A series of amino acid derivatives are successfully synthesized via a metal-free C-N coupling reaction of 5-alkoxy-3,4-dihalo-2(5H)-furanones and amino acids. Their structures are well characterized with 1H NMR, 13C NMR, ESI-MS and elemental analysis. As potential linkers of the 2(5H)-furanone unit with other drug moieties containing a hydroxyl or amino group, the effect of amino acids is investigated by comparison with other 2(5H)-furanone compounds by constructing C-O/C-S bonds. The preliminary results of the biological activity assay by the MTT method on a series of cancer cell lines in vitro reveal that the introduction of amino acids basically has no toxic effect. This can lead to these 2(5H)-furanone derivatives being further well-linked with other bioactive moieties with amino or hydroxy groups as expected. Thus, the biological activity assay gives a direction for the design of bioactive 2(5H)-furanones based on these amino acid linkers.

Sulfides, sulfones, and sulfoxides of the furan-2(5H)-one series. synthesis and structure

A number of 4- and 5-R-sulfanylfuran-2(5H)-one derivatives were synthesized, and their oxidation with various reagents was studied. The corresponding sulfones were obtained using hydrogen peroxide in acetic acid. 4-R-sulfanyl derivatives were selectively oxidized to sulfoxides with m-chloroperoxybenzoic acid. The molecular and crystal structures of some new sulfones and sulfoxides were determined by X-ray analysis.