16107-87-2

Basic information

• Product Name: 6-methyl-2,3-di-p-tolylquinoxaline
• Synonyms: 6-methyl-2,3-di-p-tolylquinoxaline
• CAS NO: 16107-87-2
• Molecular Weight: 324.425
• Mol File: 16107-87-2.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: 6-methyl-2,3-di-p-tolylquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-2,3-di-p-tolylquinoxaline(16107-87-2)
• EPA Substance Registry System: 6-methyl-2,3-di-p-tolylquinoxaline(16107-87-2)

Safety Data

• Hazardous Substances Data: 16107-87-2(Hazardous Substances Data)

Upstream product

• 3457-48-5 1,2-di(4-methylphenyl)-1,2-ethanedione 
• 89-62-3 4-methyl-2-nitroaniline 
• 5173-28-4 1,2-di-p-tolylethane-1,2-diol 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 1218-89-9 4,4'-dimethylbenzoin 

Relevant articles and documents

Room temperature facile synthesis of quinoxalines catalyzed by amidosulfonic acid

(Chemical Equation Presented) Amidosulfonic acid NH2-SO 3H catalyzed direct condensations of o-phenylenediamines with α-diketones at room temperature in organic solvents to afford quinoxalines in excellent yields. The amidosulfonic acid as a solid acid catalyst in this preparation was efficient and recoverable.

In water organic synthesis: Introducing itaconic acid as a recyclable acidic promoter for efficient and scalable synthesis of quinoxaline derivatives at room temperature

Substituted quinoxaline derivatives are traditionally synthesized by co-condensation of various starting materials. Herein, we describe a novel environmentally benign in water synthetic route for the synthesis of structurally and electronically diverse ninety quinoxalines with readily available substituted o-phenylenediamine and 1,2-diketones using cheap and biodegradable itaconic acid as a mild acid promotor in 1 hours. The reaction is performed at room temperature, which proceeds through cyclo-condensation reaction followed by obtaining the aforesaid nitrogen-containing heterocyclic adducts without performing the column chromatography up to 96% total yields. The simplicity, high efficiency, and reusable of the catalyst merits this reaction condition as “green synthesis” which enables it to be useful in synthetic transformations upto gram scale level.

Synthesis method of quinoxaline heterocyclic derivative

The invention discloses a synthesis method of a quinoxaline heterocyclic derivative. An intermolecular redox reaction and a condensation cyclization reaction are carried out on an o-nitroaniline compound and an o-diol compound under the action of a water-soluble alkali to prepare the quinoxaline heterocyclic derivative in one step. Expensive transition metal catalysts and ligands do not need to beused, the water-soluble alkali is used as an accelerant and can be removed in a water washing manner, so that the product has no transition metal residue, the product is easy to separate, the recovery rate is high, and the method is simple in condition, easy to operate and low in equipment requirement; and the water-soluble alkali is used as the accelerant, so the unique byproduct is water, the atom economy is high, and the method has good research and industrial application prospects.