1610783-41-9

Upstream product

• 160035-02-9 methyl 6-bromomethyl-4-methoxy-2-acetoxybenzoate 
• 520-43-4 2-hydroxy-4-methoxy-6-methyl-benzoic acid methyl ester 
• 15190-10-0 morpholin-4-yl-phenyl-acetonitrile 
• 870-63-3 prenyl bromide 
• 160035-01-8 methyl 2-acetoxy-4-methoxy-6-methylbenzoate 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 1610783-40-8 ethyl 2-hydroxy-4-methoxy-6-(2-oxo-2-phenylethy)benzoate 
• 109480-77-5 ethyl 2,4-dimethoxy-6-(2-oxo-2-phenylethyl)benzoate 
• 57749-86-7 ethyl 2,4-dimethoxy-6-methylbenzoate 

Downstream Products

• 1421341-46-9 8-hydroxy-6-methoxy-5-(3-methylbut-2-en-1-yl)-3-phenyl-1H-isochromen-1-one 

Relevant academic research and scientific papers

Synthesis of 3-arylisocoumarins by using acyl anion chemistry and synthesis of thunberginol A and cajanolactone A

A new strategy for the synthesis of 3-arylisocoumarins and 8-hydroxy-3-arylisocoumarins was investigated by using acyl anion chemistry for the initial C-C bond formation. The obtained keto esters and keto lactones as intermediates underwent based-promoted intramolecular cyclization to afford 3-arylisocoumarins in good yields. The developed methodology was applied for the synthesis of the important natural products thunberginol A and cajanolactone A.

First total synthesis of natural products cajanolactone A and cajanonic acid A

First total synthesis of cajanolactone A and cajanonic acid A has been achieved through steps of anion-anion condensations, cyclization, Williams etherification, selective demethylation, 1,3-sigmatropic rearrangement and hydrolysis. This work provides an efficient method for future cajanonic acid A derivatives synthesis.