16111-01-6

Upstream product

• 134-81-6 benzil 
• 91-95-2 3,3',4,4'-tetraaminobiphenyl 
• 117878-22-5 [1,1':2',1''-terphenyl]-4',5'-diamine 
• 451-40-1 phenyl benzyl ketone 
• 24242-77-1 α-iodo-α-phenylacetophenone 
• 5088-12-0 (E)-2-bromo-1,2-diphenylethenyl acetate 
• 501-65-5 diphenyl acetylene 

Relevant academic research and scientific papers

ZnO-loaded mesoporous silica (KIT-6) as an efficient solid catalyst for production of various substituted quinoxalines

Conventional homogeneous and microporous heterogeneous catalysts for quinoxalines production from diamines and diketones usually suffer from difficult separation or harsh reaction conditions. Here, we demonstrate the production of various substituted quin

Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives

Here, the hydrothermal synthesis (HTS) of 2,3-diarylquinoxalines from 1,2-diketones and o-phenylendiamines (o-PDAs) was achieved. The synthesis is simple, fast, and generates high yields, without requiring any organic solvents, strong acids or toxic catalysts. Reaction times down to 90 % in all cases). Moreover, it was shown that HTS has high compatibility: (i) hydrochlorides, a standard commercial form of amines, could be used directly as combined amine source and acidic catalyst, and (ii) Boc-diprotected o-PDA could be directly employed as substrate that underwent HT deprotection. A systematic large-scale computational comparison of all reported syntheses of the presented quinoxalines from the same starting compounds showed that this method is more environmentally friendly and less toxic than all existing methods and revealed generic synthetic routes for improving reaction yields. Finally, the application of the synthesized compounds as fluorescent dyes for cell staining was explored.

HBTU-catalyzed simple and mild protocol for the synthesis of quinoxaline derivatives

HBTU-catalyzed, simple, mild, and effective protocol for the synthesis of quinoxalines has been established. The reaction between 1,2-diamines, benzil, and catalytic amount of HBTU in ethanol resulted into quinoxalines. Various aliphatic, aromatic and het

quinoxaline dimer-containing electron transport material as organic light-emitting element

A quinoxaline dimer-containing electron transport material as an organic light-emitting element has electron-rich properties in the molecular structure. When the quinoxaline dimer-containing electrontransport material is applied to the manufacture of an organic light-emitting diode element, the quinoxaline dimer-containing electron transport material can be used as an electron-transport layer andcan promote the element to have the effect of reducing the operating voltage and improving the luminous efficiency.

Mechanochemical Synthesis, Photophysical Properties, and X-ray Structures of N-Heteroacenes

The described mechanochemical methodology is an example of a proof-of-concept in which solution-based tedious, poor yielding, and difficult syntheses of pyrazaacenes are achieved under solvent-free ball-milling conditions; the method is easy, high yieldin

N-Bromosuccinimide-Mediated Synthesis of Substituted Quinoxalines

An efficient and simple N-bromosuccinimide-mediated two-step synthesis of substituted quinoxalines from 1,2-diarylacetylenes and 1,2-diaminobenzenes in boiling AcOH, during a one-pot procedure has been developed. All the structures of the substituted quinoxalines were confirmed, some by single-crystal X-ray crystallography. Possible reaction pathways were discussed, and some data were matched with the previous work.

A selective, expeditious and sustainable entry en route to benzopyrazines and bis-benzopyrazines

A convenient green synthesis of benzopyrazines and bis-benzopyrazines has been performed by the condensation of diversely substituted diamines and dicarbonyl compounds in water using indium powder as catalyst under controlled microwave exposure. The effects of microwave power, and temperature on this reaction are investigated in detail to identify the best condition. A wide range of diversely substituted diamines and dicarbonyl compounds produce excellent yield of the corresponding benzopyrazines and bis-benzopyrazines. A comparative study has also been made between microwave-induced procedure and conventional method. The present method is atom-economical, environmentally friendly, and affords synthetically useful and challenging products very rapidly.

Poly(N,N ′-dibromo-N-ethyl-benzene-1,3-disulphonamide) and N,N,N ′,N ′-tetrabromobenzene-1,3- disulphonamide as novel catalysts for synthesis of quinoxaline derivatives

Poly(N,N ′ -dibromo-N-ethyl-benzene-1,3-disulphonamide) [PBBS] and N,N,N ′,N ′ -tetrabromobenzene-1,3- disulphonamide [TBBDA] were used as efficient catalysts for the synthesis of quinoxaline derivatives in excellent yields from 1,2-diamines and 1,2-dicarbonyls under aqueous and solvent-free conditions. [Figure not available: see fulltext.]

Logic design and synthesis of quinoxalines via the integration of iodination/oxidation/cyclization sequences from ketones and 1,2-diamines

A novel protocol for the synthesis of quinoxalines has been developed from simple ketones and 1,2-diamines. This process underwent a logic approach to bis-substituted quinoxalines via a consecutive iodination/Kornblum oxidation/cyclization in the presence of I2/CuO/DMSO and to mono-substituted quinoxalines via an iodination/cyclization/aromatization in the presence of I2/CuO/K3PO4·3H 2O.

Br?nsted acid hydrotrope combined catalyst for environmentally benign synthesis of quinoxalines and pyrido[2,3-b]pyrazines in aqueous medium

A new Br?nsted acid hydrotrope combined catalyst (BAHC) has been developed and applied in acid catalyzed synthesis of pyrido[2,3-b]pyrazines and quinoxalines in an aqueous medium at ambient temperature with excellent yields. Interestingly, the catalyst ca