16112-17-7Relevant academic research and scientific papers
A Divergent Approach to Indoles and Oxazoles from Enamides by Directing-Group-Controlled Cu-Catalyzed Intramolecular C-H Amination and Alkoxylation
Yamamoto, Chiaki,Takamatsu, Kazutaka,Hirano, Koji,Miura, Masahiro
, p. 9112 - 9118 (2017/09/11)
A directing-group-controlled, copper-catalyzed divergent approach to indoles and oxazoles from enamides has been developed. The picolinamide-derived enamides undergo the intramolecular aromatic C-H amination in the presence of a Cu(OPiv)2 catalyst and an MnO2 oxidant to form the corresponding indoles in good yields. On the other hand, simpler aryl- or alkyl-substituted enamides are converted to the 2,4,5-trisubstituted oxazole frameworks via vinylic C-H alkoxylation under identical conditions. The copper catalysis can provide uniquely divergent access to indole and oxazole heteroaromatic cores of great importance in medicinal and material chemistry.
A convenient strategy to 2,4,5-triaryl and 2-alkyl-4,5-diaryl oxazole derivatives through silver-mediated oxidative CO cross coupling/cyclization
Sarkar, Rajib,Mukhopadhyay, Chhanda
supporting information, p. 3872 - 3876 (2015/06/08)
This is a silver(I) mediated Cα(sp3)H activation of primary amines followed by oxidative CO cross coupling/cyclization for the construction of 2,4,5-triaryl and 2-alkyl-4,5-diaryl oxazole derivatives. The protocol has been successfully utilized to synthesize the oxazole derivatives in good to excellent yields. In this oxidative coupling, the silver species after the reaction was successfully re-synthesized and reused with almost a similar activity.
CuI-catalyzed and air promoted oxidative cyclization for one-pot synthesis of polyarylated oxazoles
Hu, Ping,Wang, Qiang,Yan, Yizhe,Zhang, Shuai,Zhang, Baiqun,Wang, Zhiyong
supporting information, p. 4304 - 4307 (2013/08/23)
A facile CuI-catalyzed and air promoted oxidative cyclization was developed for the synthesis of polyarylated oxazoles. By virtue of this method, a variety of arylated oxazoles could be easily synthesized from readily available starting materials at room temperature in air. The Royal Society of Chemistry 2013.
Process for the synthesis of trisubstituted oxazoles
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, (2008/06/13)
A process for the preparation of oxazoles of formula (II): by reaction of thiourea with the corresponding diketone ester.
