115377-82-7

Upstream product

• 116943-91-0 5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile 
• 104-87-0 4-methyl-benzaldehyde 
• 110212-00-5 5-benzoyl-4,5-dihydro-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile 
• 98-88-4 benzoyl chloride 
• 1218-89-9 4,4'-dimethylbenzoin 

Downstream Products

• 51490-06-3 1,2-di-p-tolyl-ethanone 
• 16178-24-8 4,5-bis-[4-(trans-2-naphthalen-1-yl-vinyl)-phenyl]-2-phenyl-oxazole 
• 16178-23-7 4,5-bis-[4-(trans-2-biphenyl-4-yl-vinyl)-phenyl]-2-phenyl-oxazole 
• 16178-22-6 2-phenyl-4,5-bis-(4-trans-styryl-phenyl)-oxazole 
• 16112-17-7 2-phenyl-4,5-(di-p-tolyl)oxazole 

Relevant academic research and scientific papers

Palladium-Catalyzed Chemo- and Enantioselective C?O Bond Cleavage of α-Acyloxy Ketones by Hydrogenolysis

A chemoselective C?O bond cleavage of the ester alkyl side-chain of α-acyloxy ketones was realized for the first time by a highly efficient palladium-catalyzed hydrogenolysis (S/C=6000, the highest catalytic efficiency by far). Furthermore, a kinetic resolution of α-acyloxy ketones was first developed by enantioselective hydrogenolysis with good yields and up to 99 % ee.

Process for the synthesis of trisubstituted oxazoles

A process for the preparation of oxazoles of formula (II): by reaction of thiourea with the corresponding diketone ester.

Studies on Pyrazolopyrimidine Derivatives. XV. Reactions Involving the Formation of the Anion of the Reissert Compound Derived form 1H-Pyrazolopyrimidine

The anion (A) of the Reissert compound (1, 5-benzoyl-4,5-dihydro-1-phenyl-1H-pyrazolopyrimidine-4-carbonitrile) was found to react with electrophiles in two ways.One is nucleophilic attack of the anion A.The other is self-decomposition of the anion A.Thus, A underwent nucleophilic attack with aromatic and aliphatic aldehydes (4a-j), resulting in the formation of the corresponding α-aryl (or alkyl)-1-phenyl-1H-pyrazolopyrimidin-4-ylmethyl benzoates (6a-j) together with 1-phenyl-1H-pyrazolopyrimidine (2), the 4,4'-dimer (7) of 2, O-benzoylaroins (8a-d), and O-benzoylcyanohydrins (9e-j).Nucleophilic substitution took place in the reaction of A with 2,4-dinitrochlorobenzene (14a) and methyl iodide (14d), giving the 4-(2,4-dinitrophenyl) derivative (17a) of 2 and 5,7-dibenzoyl-4-methyl-1-phenyl-4-(1-phenyl-1H-pyrazolopyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolopyrimidine-6-carbonitrile (19), respectively.However, the anion A did not react with other aryl (or alkyl) halides (14b, c, e), ketones (11a, b), 2-alkenonitriles (21a, b), and dimethylacetylenedicarboxylate (22), and underwent the known self-decomposition, resulting in the formation of products such as 2, 7, the cyano derivative (18) of 2, and the ester 6a.Keywords - pyrazolopyrimidine; Reissert compound; aldehyde; aryl halide; nucleophilic attack; self-decomposition; pyrazolopyrimidinemethanol