161200-70-0Relevant academic research and scientific papers
Asymmetric synthesis of 1-benzyltetrahydroisoquinolines using chiral oxazolo[2,3-a]tetrahydroisoquinolines
Hashigaki,Kan,Qais,Takeuchi,Yamato
, p. 1126 - 1131 (1991)
A novel synthetic route to enantiomerically pure 1-benzyltetrahydroisoquinolines (1) was developed via the reaction of oxazolo[2,3-a]tetrahydroisoquinoline (5) with benzyltriisopropoxytitanium compounds (10). This method was applied to the synthesis of (S)-trimetoquinol (1c; a bronchodilator).
