Asymmetric synthesis of 1-benzyltetrahydroisoquinolines using chiral oxazolo[2,3-a]tetrahydroisoquinolines

DOI: 10.1248/cpb.39.1126

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Chemical and Pharmaceutical Bulletin p. 1126 - 1131 (1991)

Update date:2022-08-02

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Authors:

Hashigaki

Kan Kan

Qais Qais

Takeuchi

Yamato Yamato

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Article abstract of DOI:10.1248/cpb.39.1126

A novel synthetic route to enantiomerically pure 1-benzyltetrahydroisoquinolines (1) was developed via the reaction of oxazolo[2,3-a]tetrahydroisoquinoline (5) with benzyltriisopropoxytitanium compounds (10). This method was applied to the synthesis of (S)-trimetoquinol (1c; a bronchodilator).

Full text of DOI:10.1248/cpb.39.1126

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