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Relevant academic research and scientific papers

Controllable Site-Selective Construction of 2- And 4-Substituted Pyrimido[1,2- b]indazole from 3-Aminoindazoles and Ynals

A straightforward and novel controllable site-selective construction of 2- and 4-substituted pyrimido[1,2-b]indazole from 3-aminoindazoles and ynals has been developed. The high regioselectivity of this reaction could be easily switched by converting different catalytic systems. In this way, a series of 2- and 4-substituted pyrimido[1,2-b]indazole derivatives were obtained in moderate to good yields. In addition, the photophysical properties of compound 3a prepared by the present method were discussed.

Method for regioselectively constructing pyrimido [1, 2-b] indazole parent nucleus

The invention relates to a method for regioselectively constructing a pyrimido [1, 2-b] indazole parent nucleus, 3-amino indazole and alkyne aldehyde are used for directly synthesizing pyrimido [1, 2-b] indazole compounds in one step, the positions of substituent groups of the products are controllable, and 2-substituted or 4-substituted products are selectively synthesized. The catalyst used in the method is safe and easy to obtain, only one part of H2O is removed after all the raw materials react from element conservation, other waste materials are not generated, post-treatment is simple, the treatment cost of reaction waste is reduced, and the method conforms to the green chemistry concept.

Aerobic α,β-C(sp3)-H Bond Difunctionalization and C-N Bond Cleavage of Triethylamine: Difunctional Ammonium Iodide Enabling the Regioselective Synthesis of 4-Arylpyrimido[1,2- b]indazoles

A novel method for the regioselective synthesis of 4-arylpyrimido[1,2-b]indazoles has been developed via the dual C(sp3)-H bond functionalization and C-N bond cleavage of triethylamine. The elusive acyclic enamine intermediates are effectively in situ generated and captured by aromatic aldehydes to form a wide array of tricyclic products from 3-aminoindazoles under the NH4I-mediated aerobic oxidative conditions. This reaction features easily available feedstock, green and economic conditions, and valuable products.

Gold/acid-co-catalyzed direct microwave-assisted synthesis of fused azaheterocycles from propargylic hydroperoxides

The gold-acid-co-catalyzed synthesis of nine series of fused azaheterocycles with structural diversity starting from the same synthons as readily available propargylic hydroperoxides and aromatic amines has been achieved. The overall tandem process consists in a gold-catalyzed hydroperoxide rearrangement/Michael reaction followed by a final acid-catalyzed cyclization.