1612226-10-4Relevant articles and documents
Copper-catalyzed synthesis of α-trifluoromethylthio-substituted ketones
Huang, Yangjie,He, Xing,Lin, Xiaoxi,Rong, Mingguang,Weng, Zhiqiang
, p. 3284 - 3287 (2014)
The CF3S-substituted moiety serves as an important structural element in many bioactive molecules. A versatile copper catalyst that allowed for trifluoromethylthiolation of primary and secondary α-bromoketones is described. The reaction with readily available elemental sulfur and CF 3SiMe3 afforded a broad scope and moderate to good yields of α-trifluoromethylthio-substituted ketones. This procedure represents a very operationally simple yet powerful strategy for the synthesis of α-trifluoromethylthio-substituted ketones, a useful and versatile class of synthetic synthons.