161275-55-4

Upstream product

• 161150-59-0 (3R)-3-amino-4-(t-butyldiphenylsilyl)oxy-2-butanone dimethyl acetal 
• 228120-04-5 (E)-4-[(3R,4R,5S)-1-allyloxycarbonyl-3,4-dibenzyloxy-5-(methanesulfonyloxy)methylpyrrolidin-2-ylidene]-2-phenyl-4H-oxazol-5-one 
• 161150-56-7 [1-(tert-butyldiphenylsilanyloxymethyl)-2-hydroxypropyl]carbamic acid benzyl ester 
• 161150-57-8 [1-(tert-butyldiphenylsilanyloxymethyl)-2-oxopropyl]carbamic acid benzyl ester 
• 161150-58-9 [1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropyl]carbamic acid benzyl ester 
• 560130-29-2 4-[(3R,4R,5S)-3,4-dibenzyloxy-5-(methanesulfonyloxy)methylpyrrolidin-2-ylidene]-2-phenyl-4H-oxazol-5-one 

Downstream Products

• 161275-56-5 (3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[1-hydroxymethyl-2,2-dimethoxypropyl]-carbamoyl]methylidene-3,4-dibenzyloxy-1-(prop-2-en-1-yloxy)carbonyl-5-(methanesulfonyloxy)methylpyrrolidine 

Relevant academic research and scientific papers

Synthetic studies of carzinophilin. Part 2: Synthesis of 3,4-dibenzyloxy-2-methylidene-1-azabicyclo[3.1.0]hexane systems corresponding to the C1-C17 fragment of carzinophilin

A model compound bearing the C1-C17 fragment of carzinophilin was synthesized. The synthesis involved coupling reaction of a cyclic thioimidate with the 4H-oxazol-5-one derivative, ring-opening of the 4H-oxazol-5-one to furnish a dehydropeptide system, elaboration of the C1-C6 enolamide, and construction of the aziridine ring as key steps.