1612757-34-2

Upstream product

• 1204750-02-6 2-(2,6-dichloro-5-ethylpyrimidin-4-yl)-2-(3,5-dimethylphenyl)acetonitrile 
• 1612757-25-1 6-[(3,5-dimethylphenyl)hydroxymethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione 
• 1612757-24-0 4-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-2,6-dimethoxypyrimidine 
• 39101-54-7 3,5-dimethylphenylacetonitrile 
• 1780-38-7 2,4,6-trichloro-5-ethylpyrimidine 
• 1612757-23-9 (3,5-dimethylphenyl)(5-ethyl-2,6-dimethoxypyrimidin-4-yl)methanol 
• 171048-68-3 (3,5-dimethylphenyl)(5-ethyl-2,6-dimethoxypyrimidin-4-yl)methanone 
• 171048-67-2 (6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine)-2,4(1H,3H)-dione 
• 1007895-03-5 1-iodo-4-(4-iodobenzyloxymethoxymethyl)benzene 
• 1612757-26-2 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethylpyrimidine-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

Synthesis of novel fluoro analogues of MKC442 as microbicides

Novel analogues of MKC442 (6-benzyl-1-(ethoxymethyl)-5-isopropylpyrimidine- 2,4(1H,3H)-dione) were synthesized by reaction of 6-[(3,5-dimethylphenyl) fluoromethyl]-5-ethyluracil (5) with ethoxymethyl chloride and formaldehyde acetals. The Sonogashira reaction was carried out on the N1-(p-iodobenzyl)oxy] methyl derivative of compound 5 using propagyl alcohol to afford compound 12 (YML220). The latter compound was selected for further studies since it showed the most potent and selective activity in vitro against wild-type HIV-1 and non-nucleoside reverse transcriptase inhibitor-, nucleoside reverse transcriptase inhibitor-, and protease inhibitor-resistant mutants and a wide range of HIV-1 clinical isolates. 12 also showed microbicidal activity in long-term assays with heavily infected MT-4 cells.