161277-46-9Relevant academic research and scientific papers
Graphite oxide catalyzed synthesis of β-amino alcohols by ring-opening of epoxides
Mirza-Aghayan, Maryam,Alvandi, Farzaneh,Molaee Tavana, Mahdieh,Boukherroub, Rabah
, p. 70 - 79 (2017/03/14)
Graphite oxide as a heterogeneous and recyclable solid acid catalyzed a simple and efficient method for the synthesis of β-amino alcohols by ring opening of epoxides with amines. This method is effective with various aromatic and aliphatic amines under solvent-free conditions. The corresponding β-amino alcohols are obtained in high yields (56%-95%) and short reaction times (15-30 min) with high regio- and chemoselectivity under metal-free conditions.
A new recyclable functionalized mesoporous SBA-15 catalyst grafted with chiral Fe(iii) sites for the enantioselective aminolysis of racemic epoxides under solvent free conditions
Halder, Mita,Bhanja, Piyali,Roy, Susmita,Ghosh, Swarbhanu,Kundu, Sudipta,Islam, Md. Mominul,Islam, Sk. Manirul
, p. 97599 - 97605 (2016/10/31)
An efficient and enantioselective strategy for the catalytic ring opening of racemic meso and terminal epoxides with aromatic as well as cyclic amine derivatives has been reported over a new mesoporous SBA-15 catalyst grafted with a chiral Fe(iii) complex
Chiral Co(III)-salen complex supported over highly ordered functionalized mesoporous silica for enantioselective aminolysis of racemic epoxides
Islam, Md. Mominul,Bhanja, Piyali,Halder, Mita,Kundu, Sudipta K.,Bhaumik, Asim,Islam, Sk. Manirul
, p. 109315 - 109321 (2016/11/30)
Here we demonstrate the synthesis of a novel chiral Co(iii)-salen complex supported functionalized 2D-hexagonal mesoporous silica material Co(iii)@AFS-1. This material has shown excellent catalytic activity for the regio- and enantioselective asymmetric ring opening (ARO) of terminal and meso epoxides using various aromatic as well as cyclic amines to produce chiral β-amino alcohols having very good enantioselectivities (ee > 99%) at ambient temperature under solvent-free neat conditions.
Resolution of racemic 2-aminocyclohexanol derivatives and their application as ligands in asymmetric catalysis
Schiffers, Ingo,Rantanen, Toni,Schmidt, Frank,Bergmans, Werner,Zani, Lorenzo,Bolm, Carsten
, p. 2320 - 2331 (2007/10/03)
A preparatively easy and efficient protocol for the resolution of racemic 2-aminocyclohexanol derivatives is described, delivering both enantiomers with >99% enantiomeric excess (ee) by sequential use of (R)- and (S)-mandelic acid. A simple aqueous workup procedure permits the isolation of the amino alcohols in analytically pure form and the almost quantitative recovery of mandelic acid. Debenzylation of enantiopure trans-2-(N-benzyl)amino-1- cyclohexanol by hydrogenation and subsequent derivatization give access to a broad variety of diversely substituted derivatives. Furthermore, the corresponding cis isomers are readily available. Applications of these optically active aminocyclohexanols in catalyzed asymmetric phenyl transfer reactions to benzaldehydes and transfer hydrogenations of aryl ketones lead to products with up to 96% ee.
Chemoenzymatic preparation of optically active β-amino-cyclohexanols and their application in the enantioselective addition of diethylzinc to benzaldehyde
Gonzalez-Sabin, Javier,Gotor, Vicente,Rebolledo, Francisca
, p. 1335 - 1341 (2007/10/03)
Optically active vesamicol and other trans-2-(N,N-dialkylamino) cyclohexanols have been easily prepared in a two step sequence: opening of the oxirane ring of cyclohexene oxide with a secondary amine and subsequent resolution of the resulting racemic amin
Aminocyclohexylesters and uses thereof
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, (2008/06/13)
Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and com
