1612775-05-9Relevant academic research and scientific papers
Ruthenium-catalyzed cross-dehydrogenative ortho-N-carbazolation of diarylamines: Versatile access to unsymmetrical diamines
Louillat, Marie-Laure,Biafora, Agostino,Legros, Fabien,Patureau, Frederic W.
supporting information, p. 3505 - 3509 (2014/04/03)
The dehydrogenative C-N cross-coupling of unprotected, secondary anilines through ortho-N-carbazolation has been achieved using a Ru catalytic system with O2 as the terminal oxidant. The reactions proceed in an intermolecular fashion, selectively in the ortho position. Implications for the field of organic synthesis are discussed. No-No-No: Amination of a non-acidic Ci￡H bond, no pre-activation of the coupling partners, no chelate-assisting directing group. Dehydrogenative C-N cross-coupling through the ortho-N-carbazolation of unprotected, secondary anilines has been achieved using a Ru catalyst with O2 as the terminal oxidant. The reactions proceed in an intermolecular fashion, selectively in the ortho position.
