1612786-69-2Relevant articles and documents
INTRODUCTION OF ALKYL SUBSTITUENTS TO AROMATIC COMPOUNDS
-
Page/Page column 43, (2016/09/15)
Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.
NIS-assisted aza-Friedel-Crafts reaction with α-carbamoysulfides as precursors of N-carbamoylimines
George, Nicolas,Bekkaye, Mathieu,Alix, Aurelien,Zhu, Jieping,Masson, Geraldine
supporting information, p. 3621 - 3625 (2014/04/03)
A general and practical N-iodosuccinimide (NIS)-promoted aza-Friedel-Crafts reaction of various aromatic nucleophiles with N-acylimines generated in situ from α-amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary.