1612786-69-2Relevant academic research and scientific papers
INTRODUCTION OF ALKYL SUBSTITUENTS TO AROMATIC COMPOUNDS
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Page/Page column 43, (2016/09/15)
Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.
Reductive Alkylation of Arenes by a Thiol-Based Multicomponent Reaction
Parnes, Regev,Pappo, Doron
supporting information, p. 2924 - 2927 (2015/06/30)
A simple and highly chemo- and regioselective method for introducing primary alkyl substituents into aromatic compounds was developed. The method is based on an electrophilic aromatic substitution of an aldehyde, promoted by a thiol, to afford 1-(alkylthio)alkylarenes, which can either be reduced in situ with triethylsilane or reacted further. This multicomponent reaction enables the direct introduction of both aromatic and linear and branched aliphatic alkyl groups into arenes. The above one-pot protocol may be performed in air and in the presence of water and is compatible with various functional groups.
NIS-assisted aza-Friedel-Crafts reaction with α-carbamoysulfides as precursors of N-carbamoylimines
George, Nicolas,Bekkaye, Mathieu,Alix, Aurelien,Zhu, Jieping,Masson, Geraldine
supporting information, p. 3621 - 3625 (2014/04/03)
A general and practical N-iodosuccinimide (NIS)-promoted aza-Friedel-Crafts reaction of various aromatic nucleophiles with N-acylimines generated in situ from α-amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary.
