1612882-49-1

Basic information

• Product Name: C₁₄H₁₈O₄
• Synonyms: C₁₄H₁₈O₄
• CAS NO: 1612882-49-1
• Molecular Weight: 250.295
• Mol File: 1612882-49-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₈O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₈O₄(1612882-49-1)
• EPA Substance Registry System: C₁₄H₁₈O₄(1612882-49-1)

Safety Data

• Hazardous Substances Data: 1612882-49-1(Hazardous Substances Data)

Upstream product

• 147514-19-0 S-(-)-1-bromo-2-phenylpropane 
• 108-59-8 malonic acid dimethyl ester 
• 446879-29-4 (S)-(2-iodo-1-methylethyl)benzene 
• 37778-99-7 (S)-2-phenyl-1-propanol 
• 1333203-99-8 C₁₅H₁₄OS₂ 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 2406-18-0 methyl (R)-(-)-4-phenylpentanoate 
• 16433-43-5 (R)-4-phenylpentanoic acid 

Relevant articles and documents

Non- C2-Symmetric Chiral-at-Ruthenium Catalyst for Highly Efficient Enantioselective Intramolecular C(sp3)-H Amidation

A new class of chiral ruthenium catalysts is introduced in which ruthenium is cyclometalated by two 7-methyl-1,7-phenanthrolinium heterocycles, resulting in chelating pyridylidene remote N-heterocyclic carbene ligands (rNHCs). The overall chirality results from a stereogenic metal center featuring either a or Δabsolute configuration. This work features the importance of the relative metal-centered stereochemistry. Only the non-C2-symmetric chiral-at-ruthenium complexes display unprecedented catalytic activity for the intramolecular C(sp3)-H amidation of 1,4,2-dioxazol-5-ones to provide chiral -lactams with up to 99:1 er and catalyst loadings down to 0.005 mol % (up to 11 ?200 TON), while the C2-symmetric diastereomer favors an undesired Curtius-type rearrangement. DFT calculations elucidate the origins of the superior C-H amidation reactivity displayed by the non-C2-symmetric catalysts compared to related C2-symmetric counterparts.