1613250-66-0Relevant articles and documents
Transition Metal-Free de Novo Synthesis of Sulfonated Pyrazoles from Sulfonyl Hydrazides, 1,3-Diketones, and Sodium Sulfinates at Room Temperature
Chen, Jiawen,Chen, Dongwei,Kuang, Jinqiang,Ma, Yongmin
, p. 9289 - 9298 (2021)
A transition metal-free method for de novo construction of diverse sulfonated pyrazoles from readily available sulfonyl hydrazides, 1,3-diketones, and sodium sulfinates was established under mild conditions. Pyrazoles bearing two different sulfonyl groups were obtained in one step. The method features a diversity of substituents of the pyrazole products and a remarkably simple work-up.
1, 4-disulfonylated fully-substituted pyrazole compound, and preparation method and application thereof
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Paragraph 0060; 0109-0112, (2021/06/21)
The invention discloses a 1, 4-disulfonylated fully-substituted pyrazole compound, and a preparation method and application thereof. A sulfonyl hydrazine compound, a 1, 3-dicarbonyl compound and a sodium sulfinate compound are subjected to a multi-component reaction in a solvent under the combined action of elemental iodine and an alkali to prepare a 1, 4-disulfonylated 1, 3, 4, 5-tetra-substituted pyrazole compound by a one-pot method. The structural general formula of the 1, 4-disulfonylated fully-substituted pyrazole compound is shown in the specification. In the formula, R, R and R are respectively and independently selected from an aryl group, a heteroaryl group or a fatty group, and R and R are different; R3 is a fatty group; and the aryl group, the heteroaryl group or the fatty group is optionally substituted by 1-5 substituent groups. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, diversified structures, mild reaction conditions and simple post-treatment, and has potential industrialization prospects.
The containing of the method for the preparation of substituted pyrazole
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Paragraph 0091; 0092; 0093, (2016/10/07)
The invention discloses a preparation method of sulfonyl-containing completely substituted parazole. The preparation method of the sulfonyl-containing completely substituted parazole comprises the step of carrying out a condensation reaction on 1,3-diketone and aromatic sulfonyl hydrazine as reaction substrates, iodide as a catalyst, peroxy-tertiary butanol as an oxidant, and cobalt acetate tetrahydrate or anhydrous cobalt chloride as an additive in ethyl acetate or benzene as a solvent, so that the sulfonyl-containing completely substituted parazole is obtained. The preparation method disclosed by the invention has the advantages that good and even excellent yield can be realized for multiple aryl sulfonyl hydrazides and 1,3-diketones, and the highest yield can be 97%; compatibility of functional groups of the substrates is high, and application range of the substrates is wide compared with the traditional method; meanwhile, a preparation process is controllable, so that the preparation method disclosed by the invention is applicable to industrial production of the sulfonyl-containing completely substituted parazole.
Dual roles of sulfonyl hydrazides: A three-component reaction to construct fully substituted pyrazoles using TBAI/TBHP
Zhang, Jie,Shao, Ying,Wang, Hongxiang,Luo, Qiang,Chen, Jijun,Xu, Dongmei,Wan, Xiaobing
supporting information, p. 3312 - 3315 (2014/07/08)
A mild and rapid approach has been developed for the construction of fully substituted pyrazoles using TBAI as a catalyst and TBHP as an oxidant, in which tosylhydrazide functions as the ring component and sulfonyl precursor. This protocol features a wide substrate scope with a broad range of functional group tolerance, utilizes easily available starting materials, can be scaled-up, and is operationally simple.
