3002-23-1Relevant articles and documents
Hill et al.
, p. 602,604 (1959)
Promiscuous substrate binding explains the enzymatic stereoand regiocontrolled synthesis of enantiopure hydroxy ketones and diols
Kurina-Sanz, Marcela,Bisogno, Fabricio R.,Lavandera, Ivan,Orden, Alejandro A.,Gotor, Vicente
supporting information; experimental part, p. 1842 - 1848 (2011/02/25)
Regio- and stereoselective reductions of several diketones to afford enantiopure hydroxy ketones or diols were accomplished using isolated alcohol dehydrogenases (ADHs). Results could be rationalised taking into account different (promiscuous) substrate-binding modes in the active site of the enzyme. Furthermore, interesting natural cyclic diketones were also reduced with high regio- and stereoselectivity. Some of the 1,2 and 1,3-diketones used in this study were reduced by employing a low excess of the hydrogen donor (2-propanol) due to the quasi-irreversibility of these ADH-catalysed processes. Thus, using lower quantities of co-substrate, scale-up could be easily achieved.
kINETICS AND MECHANISM OF THE REACTION OF IRON(III) WITH 6-METHYL-2,4-HEPTANEDIONE AND 3,5-HEPTANEDIONE
Hernando, Jose M.,Montero, Olimpio,Blanco, Carlos
, p. 1984 - 1990 (2007/10/02)
The kinetics of the reactions of iron(III) with 6-methyl-2,4-heptanedione and 3,5-heptanedione to form the corresponding monocomplexes have been studied spectrophotometrically in the range 5 deg C to 16 deg C at Ι 25 mol 1-1 in aqueous solution.In the proposed mechanism for the two complexes, the enol form reacts with the metal ion by parallel acid-independent and inverse-acid paths.The kinetic constants for both pathaways have been calculated at five temperatures.Activation parameters have also been calculated.The results are consistent with an associative activation for Fe(H2O)63+ and dissociative activation for Fe(H2O)5(OH)2+.The differences in the results for the complexes of heptanediones studied are interpreted in terms of steric factors.
