1613293-50-7

Basic information

• Product Name: C₂₃H₂₀ClFN₄O₄
• CAS NO: 1613293-50-7
• Molecular Weight: 470.888
• Mol File: 1613293-50-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₀ClFN₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₀ClFN₄O₄(1613293-50-7)
• EPA Substance Registry System: C₂₃H₂₀ClFN₄O₄(1613293-50-7)

Safety Data

• Hazardous Substances Data: 1613293-50-7(Hazardous Substances Data)

Upstream product

• 446-32-2 4-fluoroanthranilic acid 
• 16499-57-3 7-fluoro-3,4-dihydroquinazolin-4-one 
• 162012-69-3 7-fluoro-6-nitro-4-hydroxyquinazoline 
• 162012-70-6 4-chloro-7-fluoro-6-nitroquinazoline 
• 162012-67-1 N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 
• 314771-88-5 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 
• 314771-76-1 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 
• 1613293-57-4 C₁₉H₁₇ClFN₃O₂ 
• 1613293-58-5 C₁₉H₁₆BrClFN₃O₂ 
• 37772-89-7 pyrrolidine-2,4-dione 

Relevant articles and documents

TARGETED COVALENT PROBES AND INHIBITORS OF PROTEINS CONTAINING REDOX-SENSITIVE CYSTEINES

Covalent, irreversible small-molecule inhibitors that modify the sulfenyl form (i.e., sulfenic acid, RSOH and sulfenamide, RSNR'2) of therapeutically important proteins (particularly kinases and phosphatases) are disclosed, where the compositions include a compound having a substituted aryl or heterocyclic core structure that promotes binding interactions with a specific protein, and a nucleophilic reaction center (carbon, nitrogen, sulfur, or phosphorous) that is capable of forming a covalent bond with a sulfenic acid- or sulfenamide-modified cysteine residue in the protein. Methods for synthesizing these compounds are also disclosed, as well as methods of using them for determining the bioactivity of a chemical composition comprising an active compound toward a specific protein and for determining the potency of an inhibitor against a specific protein.