1613329-98-8Relevant articles and documents
The bridge ring piperazine derivative or its salt and its preparation and use (by machine translation)
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, (2019/01/23)
The invention belongs to the technical field of chemical medicine, relates to bridge piperazine derivative or its salt and its preparation method, and the states the bridge arch piperazine derivative or a salt thereof in the preparation in the treatment of diseases associated with the ROR γ t use in the medicament. By experiment, the results display, of the bridge of the present invention can effectively inhibit the piperazine derivatives ROR γ t protein receptor, regulating Th17 cell differentiation, inhibiting IL - 17 production, can be further used to treat ROR γ t-mediated inflammation-related drug for the treatment of such diseases, especially suitable for the treatment of multiple sclerosis, rheumatoid arthritis, collagen induced arthritis, psoriasis, inflammatory bowel disease, encephalomyelitis, cloning disease, asthma, inflammation-related diseases such as cancer. (by machine translation)
Novel compounds
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, (2017/09/27)
The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.
NOVEL COMPOUNDS
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, (2015/12/17)
Disclosed are novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.