16141-16-5

Upstream product

• 7553-56-2 iodine 
• 536-74-3 phenylacetylene 
• 66288-38-8 α,β-diiodo-cinnamic acid 

Downstream Products

• 536-74-3 phenylacetylene 
• 58-72-0 Triphenylethylene 
• 100-42-5 styrene 

Relevant academic research and scientific papers

Direct iodination of monosubstituted aryl acetylenes and acetylenic ketones

Monosubstituted acetylenes were iodinated to form iodoacetylenes under simple conditions. Reaction of aryl acetylenes with molecular iodine in the presence of 4-dimethylaminopyridine (DMAP) gave the desired products in good to excellent yields. Iodination

Synthesis and Photochemical Application of Hydrofluoroolefin (HFO) Based Fluoroalkyl Building Block

A novel fluoroalkyl iodide was synthesized on multigram scale from refrigerant gas HFO-1234yf as cheap industrial starting material in a simple, solvent-free, and easily scalable process. We demonstrated its applicability in a metal-free photocatalytic ATRA reaction to synthesize valuable fluoroalkylated vinyl iodides and proved the straightforward transformability of the products in cross-coupling chemistry to obtain conjugated systems.

Efficient synthesis of 1-iodoalkynes: Via Al2O3 mediated reaction of terminal alkynes and N -iodosuccinimide

Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al2O3 was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.

Hypervalent Iodine Mediated Chemoselective Iodination of Alkynes

Reported herein are practical approaches for the chemoselective mono-, di-, and tri-iodination of alkynes based on efficient oxidative iodinations catalyzed by hypervalent iodine reagents. The reaction conditions were systematically optimized by altering

A high-selective synthesis of 1, 2 - two iodine alkene hydrocarbon compounds (by machine translation)

This application pertains to the technical field of synthetic chemistry, in particular to a high selective synthesis of 1, 2 - two iodine alkene hydrocarbon compounds. The present invention provides a method of mild reaction conditions, the reaction produ

Synthesis method of 1,2-diiodoolefine compound

The invention discloses a synthesis method of a 1,2-diiodoolefine compound. In an environment capable of avoiding air contact, a phenylacetylene reaction substrate and reagents including zinc diiodide and tert-butyl nitrite are put into a solution and rea

Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles: Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling

Iodo-1,2,3-triazoles are of considerable interest for chemical and biomedical applications. However, current synthetic methods for preparing iodo-1,2,3-triazoles cannot easily be applied to the direct modification of bioactive molecules in water. Through

Tuning radical reactivity using iodine in oxidative C(sp3)-H/C(sp)-H cross-coupling: An easy way toward the synthesis of furans and indolizines

Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C-I bond formation for co

Odorless, One-Pot Regio- and Stereoselective Iodothiolation of Alkynes with Sodium Arenesulfinates under Metal-Free Conditions in Water

A newly developed regio- and stereoselective radical addition of alkyne under metal-free conidtions has been disclosed. This chemistry, in which odorless sodium arenesulfinates in place of thiols are used as the sulfur reagent, provides an efficient, one-pot approach for the generation of β-iodoalkenyl sulfides, which can be easily further functionalized to derive various alkenes and alkynyl sulfides rendering this methodology attractive to both synthetic and medicinal chemistry. (Chemical Equation Presented).

Mild and efficient oxy-iodination of alkynes and phenols with potassium iodide and tert-butyl hydroperoxide

An efficient synthesis of 1-iodoalkynes and iodophenols was easily achieved by employing simple KI and TBHP. The reaction does not involve the use of a metal and base combination. A variety of substituted alkynes and phenols were prepared with good to excellent yield.