16141-18-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethynylphenyl acetate is used as an intermediate in the synthesis of various pharmaceuticals due to its versatile chemical structure and reactivity.
Used in Flavoring and Fragrance Industry:
4-Ethynylphenyl acetate is used as a flavoring agent in the food and beverage industry, adding unique aromatic notes to products.
Used in Material Science:
4-Ethynylphenyl acetate is used in the development of new materials such as polymers and coatings, leveraging its strong aromatic properties and potential for chemical modification.

InChI:InChI=1/C10H8O2/c1-3-9-4-6-10(7-5-9)12-8(2)11/h1,4-7H,2H3

Upstream product

• 33527-94-5 4-acetoxyiodobenzene 
• 540-38-5 p-Iodophenol 
• 1927-95-3 4-bromophenyl acetate 
• 165825-13-8 4-((2-trimethylsilyl)ethynyl)phenyl acetate 

Downstream Products

• 136781-96-9 rubrolide D diacetate 
• 1028293-57-3 (Z)-7-{(1S,2R,3R,4R)-3-[4-(4-Acetoxy-phenylethynyl)-3-nitro-benzenesulfonylamino]-bicyclo[2.2.1]hept-2-yl}-hept-5-enoic acid methyl ester 
• 1232860-68-2 diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate 
• 1155883-51-4 4-methoxy-2-(4-hydroxyphenyl)quinoline 
• 148-86-7 4-acetoxybiphenyl 
• 108368-43-0 4-(5,7-dimethyl-4-oxo-4H-chromen-2-yl)phenyl acetate 
• 1030386-02-7 4-benzyl-5R-phenyl-3R-(E-2-(4-acetoxyphenyl)ethenyl)-morpholin-2-one 

Relevant academic research and scientific papers

Hydrosoluble and solvatochromic naphthalene diimides with NIR absorption

Mimicking biochromophore anions containing phenolate moieties, eight conjugated naphthalene diimides (NDIs) have been synthesized in order to develop probes, displaying charge-transfer transitions affected by the nearby environment. NIR absorption of the resulting phenolates and their solvatochromic properties in both organic solvents and water are described.

Nickel-Catalyzed Decarbonylative Cycloaddition of Benzofuran-2,3-diones with Alkynes to Flavones

Using dppe as the ligand, the Nickel-catalyzed decarbonylative cycloaddition of benzofuran-2,3-diones with alkynes was established, and a variety of functional flavones were synthesized in 65–99% yields. Terminal alkynes with substituted phenyl groups and internal alkynes such as aryl acyl acetylenes and diphenylacetylenes are suitable for this reaction. The effects of bases on the reactions of different types of alkyne substrates were also investigated and discussed. (Figure presented.).

Regio- and stereoselective synthesis of bromoalkenes by homolytic hydrobromination of alkynes with hydrogen bromide

Homolytic hydrobromination of terminal and internal alkynes with a commercially available solution of hydrogen bromide in acetic acid has been investigated for regio- and stereoselective synthesis of bromoalkenes. Under an aerobic atmosphere at room temperature, the reaction of ethynylarenes with a small excess of HBr efficiently gave (2-bromoethenyl)arenes with good to high E-selectivity. (Alk-1-ynyl)arenes, or internal alkynes bearing both phenyl and alkyl groups at the sp-carbons also underwent the air-initiated hydrobromination to exhibit high Z-selectivity under kinetic conditions using a half equivalent of HBr.

Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly

This paper presents an enzyme building block for the assembly of megamolecules. The system is based on the inhibition of the human-derived cellular retinoic acid binding protein II (CRABP2) domain. We synthesized a synthetic retinoid bearing an arylfluoro

Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines

Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea

Acyl-based donor molecules

Problem: To provide acyl-based donor molecules that enable acylization of the target molecule at high efficiency and acylizing agents using the molecule as an active ingredient.Solution: Compounds having the following structure and acylated agents using the compound as an active ingredient.【Chemical 1】(R indicates acyl group, X indicates hydrophilic group)【Selection diagram】 None

Extended Naphthalene Diimides with Donor/Acceptor Hydrogen-Bonding Properties Targeting G-Quadruplex Nucleic Acids

Naphthalene diimides with one or two centrosymmetric arylethynyl moieties capable of synergic donor and acceptor hydrogen bonding exhibit promising binding properties and selectivity towards parallel G-quadruplex (G4) nucleic acids (c-myc, bcl-2 and parallel hTel22). The hydrogen-bonding network involving the phosphate backbone and outside rim of the G-quartet represents an opportunity to exploit G4 selectivity for extended aromatics.

Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments: From Waste to Antioxidants and Antitumour Compounds

Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells.

Reactivity switch enabled by counterion: Highly chemoselective dimerization and hydration of terminal alkynes

A counterion-controlled reactivity tuning in Pd-catalyzed highly chemoselective and regioselective dimerization and hydration of terminal alkynes is reported. The use of acetate as counterion favors the formation of an alkenyl alkynyl palladium intermediate which forms hitherto less reported 1,3-diaryl-substituted conjugated enynes after reductive elimination. Using chloride, which is a better leaving group, leads to anion exchange on the alkenylpalladium intermediate with hydroxide which after reductive elimination and tautomerization delivered the hydration products.

THIAZOLE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS

The present invention provides thiazole derivatives as Stearoyl CoA Desaturase (SCD) inhibitors. In particular, the compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase