33527-94-5

Basic information

• Product Name: 4-IODOPHENYLACETATE
• Synonyms: 4-IODOPHENYLACETATE;1-Acetoxy-4-iodobenzene;1-Iodo-4-acetoxybenzene;Acetic acid 4-iodophenyl ester;4-iodo-Phenol, acetate
• CAS NO: 33527-94-5
• Molecular Formula: C₈H₇IO₂
• Molecular Weight: 262.04445
• Mol File: 33527-94-5.mol
• Article Data: 46

Chemical Properties

• Melting Point: 38 °C
• Boiling Point: 271°Cat760mmHg
• Flash Point: 117.7°C
• Appearance: /
• Density: 1.757g/cm³
• Vapor Pressure: 0.00662mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 4-IODOPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODOPHENYLACETATE(33527-94-5)
• EPA Substance Registry System: 4-IODOPHENYLACETATE(33527-94-5)

Safety Data

• Hazardous Substances Data: 33527-94-5(Hazardous Substances Data)

Usage

General Description

4-Iodophenylacetate is a chemical compound that consists of a phenyl ring with an iodine substitution at the para position and an acetate group attached to the benzene ring. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. This chemical has various applications in organic chemistry, such as in the preparation of esters, amides, and other organic compounds. It is an important building block for the synthesis of biologically active molecules and has been studied for its potential pharmacological properties. Its structure and reactivity make it a versatile compound for use in organic synthesis and drug development.

InChI:InChI=1/C8H7IO2/c1-6(10)11-8-4-2-7(9)3-5-8/h2-5H,1H3

Upstream product

• 540-38-5 p-Iodophenol 
• 108-24-7 acetic anhydride 
• 122-79-2 Phenyl acetate 
• 13329-40-3 4-Iodoacetophenone 
• 591-50-4 iodobenzene 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 123-30-8 4-amino-phenol 
• 17881-56-0 1-iodo-4-(trimethylsilyl)benzene 
• 64-19-7 acetic acid 
• 13132-25-7 4-(trimethylsilyl)phenol 
• 506-96-7 Acetyl bromide 
• 116568-30-0 acetic acid-(4-dichloroiodanyl-phenyl ester) 
• 134856-56-7 C₁₂H₁₇N₃O₂ 
• 74-88-4 methyl iodide 

Downstream Products

• 7191-41-5 1-(2-hydroxy-5-iodophenyl)ethan-1-one 
• 116568-30-0 acetic acid-(4-dichloroiodanyl-phenyl ester) 
• 21250-00-0 1,3-Bis-(4-acetoxy-phenyl)-perfluor-propan 
• 25444-23-9 4-Acetoxy-1-(3H-perfluor-propyl)-benzol 
• 110396-59-3 Acetic acid 4-(1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-3-yl)-phenyl ester 
• 155589-46-1 ethyl 4-(4-acetoxyphenyl)butanoate 
• 720-75-2 methyl 4-phenylbenzoate 
• 29886-65-5 4-thiophen-2-yl-phenol 
• 492-97-7 2,2'-Bithiophene 
• 127977-21-3 benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-(4'-acetoxyphenyl)propionate 
• 17595-86-7 methyl 4-(2-thienyl)benzoate 
• 16141-18-7 para-acetoxyphenylacetylene 
• 122-79-2 Phenyl acetate 
• 127783-75-9 4'-cyano-[1,1'-biphenyl]-4-yl acetate 

Relevant articles and documents

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.

Permeant fluorescent probes visualize the activation of sarm1 and uncover an antineurodegenerative drug candidate

SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, which exhibited large red shifts after conversion. With the conjugates, SARM1 activation was visualized in live cells following elevation of endogenous NMN or treatment with a cell-permeant NMN-analog. In neurons, imaging documented mouse SARM1 activation preceded vincristine-induced axonal degeneration by hours. Library screening identified a derivative of nisoldipine (NSDP) as a covalent inhibitor of SARM1 that reacted with the cysteines, especially Cys311 in its ARM domain and blocked its NMN-activation, protecting axons from degeneration. The Cryo-EM structure showed that SARM1 was locked into an inactive conformation by the inhibitor, uncovering a potential neuroprotective mechanism of dihydropyridines.

Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines

Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea